Ishikawa Akira, Kuraoka Kazuya, Zaitsu Junichi, Saito Akihisa, Kuwai Toshio, Suzuki Takahisa, Tashiro Hirotaka, Taniyama Kiyomi, Yasui Wataru
Department of Clinical Laboratory, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama, Kure 737-0023, Japan.
Department of Diagnostic Pathology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama, Kure 737-0023, Japan.
Acta Histochem Cytochem. 2020 Oct 29;53(5):113-119. doi: 10.1267/ahc.20-00014. Epub 2020 Sep 24.
Gastric cancer (GC) is the third most common cause of cancer-related mortality. The diagnosis and treatment of early GC is a crucial strategy for prognostic improvement of GC. Annexin A10 (ANXA10), a calcium-/phospholipid-binding protein, is a member of the annexin family. The significance of ANXA10 expression in early GC remains unclear. This is the first report to investigate ANXA10 expression in early GC. We performed immunohistochemistry to evaluate ANXA10 expression in early GC, and the correlation between ANXA10 and clinicopathological factors. The loss of ANXA10 expression was detected in 63 (61.2%) of 103 early GC cases and significantly correlated with poor overall survival in patients. Sex, pT stage, pN stage, histology, and ANXA10 expression were associated with poor survival. Sex, histology, and ANXA10 expression were determined as independent predictors of survival in early GC patients. ANXA10 immunostaining could be a new decision-making biomarker in GC.
胃癌（GC）是癌症相关死亡的第三大常见原因。早期胃癌的诊断和治疗是改善胃癌预后的关键策略。膜联蛋白A10（ANXA10）是一种钙/磷脂结合蛋白，属于膜联蛋白家族成员。ANXA10在早期胃癌中的表达意义尚不清楚。这是首篇研究早期胃癌中ANXA10表达的报告。我们进行了免疫组织化学以评估早期胃癌中ANXA10的表达，以及ANXA10与临床病理因素之间的相关性。在103例早期胃癌病例中的63例（61.2%）检测到ANXA10表达缺失，且与患者较差的总生存期显著相关。性别、pT分期、pN分期、组织学类型以及ANXA10表达与较差的生存率相关。性别、组织学类型以及ANXA10表达被确定为早期胃癌患者生存的独立预测因素。ANXA10免疫染色可能成为胃癌中一种新的决策生物标志物。
