Alt F W, Blackwell T K, Yancopoulos G D
Department of Biochemistry, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
Science. 1987 Nov 20;238(4830):1079-87. doi: 10.1126/science.3317825.
The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.
产生多样化免疫反应的能力取决于编码免疫球蛋白分子抗原结合部分的基因的体细胞组装。在本文中，我们讨论了这些基因组重排事件的机制和调控，以及该过程的各个方面如何参与产生初始抗体库。
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