一种具有翻转外部酯基设计的新型牙科聚合物，通过聚合物主链的保护来抵抗降解。
A Novel Dental Polymer with a Flipped External Ester Group Design that Resists Degradation via Polymer Backbone Preservation.
机构信息
Division of Pediatric Dentistry, School of Dentistry, University of Minnesota, Moos Health Science Tower, 515 Delaware Street S.E. Minneapolis, MN 55455.
TDA Research Inc., 12345 W. 52 Ave., Wheat Ridge, CO 80033.
出版信息
ACS Biomater Sci Eng. 2020 Oct 12;6(10):5609-5619. doi: 10.1021/acsbiomaterials.0c00947. Epub 2020 Sep 28.
Current dental sealants with methacrylate based chemistry are prone to hydrolytic degradation. A conventional ethylene glycol dimethacrylate (EGDMA) was compared to a novel methacrylate monomer with a flipped external ester group (ethylene glycol ethyl methacrylate - EGEMA) that was designed to resist polymer degradation effects. Fourier transform infrared spectroscopy and water contact angle confirmed a comparable degree of initial conversion and surface wettability for EGDMA and EGEMA. EGDMA disks initially performed better compared to EGEMA as suggested by higher surface hardness and 1.5 times higher diametral tensile strength (DTS). After 15 weeks of hydrolytic and accelerated aging, EGDMA and EGEMA DTS was reduced by 88% and 44% respectively. This accelerated aging model resulted in 3.3 times higher water sorption for EDGMA than EGEMA disks. EGDMA had an increase in grain boundary defects and visible erosion sites with accelerated aging, while for EGEMA the changes were not significant.
目前基于甲基丙烯酸酯化学的牙科密封剂容易发生水解降解。将传统的乙二醇二甲基丙烯酸酯（EGDMA）与一种新型的具有翻转的外部酯基的甲基丙烯酸酯单体（乙二醇乙基甲基丙烯酸酯 - EGEMA）进行了比较，后者旨在抵抗聚合物降解效应。傅里叶变换红外光谱和水接触角证实了 EGDMA 和 EGEMA 具有相当程度的初始转化率和表面润湿性。EGDMA 圆盘的初始性能优于 EGEMA，表现为更高的表面硬度和 1.5 倍更高的直径拉伸强度（DTS）。经过 15 周的水解和加速老化后，EGDMA 和 EGEMA 的 DTS 分别降低了 88%和 44%。这种加速老化模型导致 EDGMA 比 EGEMA 盘的吸水率高 3.3 倍。EGDMA 在加速老化过程中出现了晶界缺陷和明显的侵蚀部位的增加，而对于 EGEMA，变化不明显。
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