J Pytko-Polonczyk J, Jakubik A, Przeklasa-Bierowiec A, Muszynska B
Department of Integrated Dentistry, Jagiellonian University Medical College, Cracow, Poland.
Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland.
J Physiol Pharmacol. 2017 Dec;68(6):807-813.
Examination of dental materials and their properties at the initial stage of the digestive process requires the development of conditions that mimic the environment of the oral cavity. One of the main components of this area is saliva, where many reactions occur under natural conditions. Human saliva is an important physiological fluid that is essential for the maintenance of good oral health and of the entire human body; it is the place where digestion begins and thus contributes to the supply of those nutrients and health-promoting substances that are essential to the body but may also cause release of potential toxins. Thereby, the main aim of the study was to review the use of artificial saliva models in the context of stomatological and biological research. Biological studies have shown that the amount of biologically active substances in biological material is not the same as their quantity released under the conditions of the human digestive system and thus bioavailable to it. These results show that tables of active ingredients in drugs and food stuffs do not present their actual usefulness and availability to the human body.
在消化过程的初始阶段对牙科材料及其性能进行检测，需要营造出模拟口腔环境的条件。该领域的主要成分之一是唾液，在自然条件下会发生许多反应。人类唾液是一种重要的生理流体，对保持良好的口腔健康乃至整个人体健康至关重要；它是消化开始的地方，因此有助于提供对身体必不可少但也可能导致潜在毒素释放的营养物质和促进健康的物质。因此，本研究的主要目的是在口腔学和生物学研究的背景下，综述人工唾液模型的应用。生物学研究表明，生物材料中生物活性物质的含量与它们在人类消化系统条件下释放并因此对其具有生物利用度的量并不相同。这些结果表明，药品和食品中的活性成分表并不能体现它们对人体的实际效用和可利用性。
