Department of Neurology, Christian Medical College, Vellore, India.
Department of Clinical Microbiology, Christian Medical College, Vellore, India.
J Peripher Nerv Syst. 2021 Mar;26(1):90-98. doi: 10.1111/jns.12422. Epub 2020 Nov 18.
Limited literature is available on stimulus induced after discharges (SIAD) in patients with peripheral nerve hyperexcitability (PNH). The aim of the study was to examine the diagnostic utility of SIAD in the diagnosis and monitoring of primary PNH disorders. In this retrospective study, we studied 26 patients who were admitted with a diagnosis of primary PNH to the department of Neurology from January 2013 to April 2019. Their clinical profile, immunological characteristics were extracted from the database and nerve conduction studies were relooked for the presence of SIAD. 76% of patients in the primary PNH cohort had SIAD with 90% of them being voltage-gated potassium channel complex antibody positive; predominantly against contactin-associated protein-2 antigen and rest being paraneoplastic. There was also resolution of SIAD following treatment indicating reversible hyperexcitability. SIAD is a sensitive marker for Primary PNH syndrome with monitoring and diagnostic implications.
关于外周神经兴奋性过高（PNH）患者刺激诱导后放电（SIAD）的文献有限。本研究的目的是检验 SIAD 在原发性 PNH 疾病的诊断和监测中的诊断效用。在这项回顾性研究中，我们研究了 2013 年 1 月至 2019 年 4 月期间因原发性 PNH 被收入神经科的 26 名患者。从数据库中提取了他们的临床特征和免疫特征，并重新进行神经传导研究以寻找 SIAD 的存在。原发性 PNH 组中有 76%的患者存在 SIAD，其中 90%的患者电压门控钾通道复合物抗体阳性；主要针对接触蛋白-2 抗原，其余为副肿瘤性。SIAD 也随着治疗而消失，表明存在可逆性兴奋性过高。SIAD 是原发性 PNH 综合征的敏感标志物，具有监测和诊断意义。
