NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country (UPV/EHU), School of Pharmacy, Paseo de la Universidad 7, Vitoria- Gasteiz 01006, Spain; Biosasun S.A, Iturralde 10, Etxabarri-Ibiña, Zigoitia 01006, Spain.
Biosasun S.A, Iturralde 10, Etxabarri-Ibiña, Zigoitia 01006, Spain.
Biotechnol Adv. 2021 Jan-Feb;46:107657. doi: 10.1016/j.biotechadv.2020.107657. Epub 2020 Nov 9.
The use of nanotechnology has revolutionized many biotechnological sectors, from bioengineering to medicine, passing through food and cosmetic fields. However, their clinic and industrial application has been into the spotlight due to their safety risk and related side effects. As a result, Green Nanoscience/Nanotechnology emerged as a strategy to prevent any associated nanotoxicity, via implementation of sustainable processes across the whole lifecycle of nanoformulation. Notwithstanding its success across inorganic nanoparticles, the green concept for organic nanoparticle elaboration is still at its infancy. This, coupled with the organic nanoparticles being the most commonly used in biomedicine, highlights the need to implement specific green principles for their elaboration. In this review, we will discuss the possible green routes for the proper design of organic nanoparticles under the umbrella of Green Nanoscience: from the extraction of nanomaterials and active compounds to their final nanoformulation.
纳米技术的应用已经彻底改变了许多生物技术领域，从生物工程到医学，再到食品和化妆品领域。然而，由于其安全风险和相关副作用，它们的临床和工业应用受到了关注。因此，绿色纳米科学/纳米技术作为一种策略出现了，旨在通过在纳米制剂的整个生命周期内实施可持续的工艺来防止任何相关的纳米毒性。尽管它在无机纳米粒子方面取得了成功，但有机纳米粒子的绿色概念仍处于起步阶段。这一点，加上有机纳米粒子是生物医学中最常用的，突出了需要为其开发制定具体的绿色原则。在这篇综述中，我们将讨论在绿色纳米科学的框架下，对有机纳米粒子进行适当设计的可能的绿色途径：从纳米材料和活性化合物的提取到最终的纳米制剂。
