Markwardt F
Institut für Pharmakologie und Toxikologie, Medizinischen Akademie Erfurt.
Z Gesamte Inn Med. 1987 Sep 1;42(17):473-8.
Increasing insight into the mechanisms of fibrinolysis, and particularly into the formation and release of plasminogen activator, has led to more effective thrombolytic therapy. The understanding of the mechanism of thrombolysis has provided the possibility to improve the therapeutic effects of the fibrinolytic agents streptokinase and urokinase. Further advances in thrombolytic therapy are expected by the use of the plasminogen activator from endothelium and pro-urokinase. Acylation of fibrinolytic enzymes will lead to beneficial effects (depot effect, protection from intrinsic inhibitors). Due to the extensive research into substances with fibrinolytic and thrombolytic effects a new generation of activators of fibrinolysis is expected that interferes with the biosynthesis and release of plasminogen activator of the vessel wall and that is suited for treatment of hypofibrinolytic states.
对纤维蛋白溶解机制，尤其是对纤溶酶原激活物的形成和释放的深入了解，已带来了更有效的溶栓治疗。对溶栓机制的认识为提高纤维蛋白溶解剂链激酶和尿激酶的治疗效果提供了可能。通过使用来自内皮的纤溶酶原激活物和尿激酶原，有望在溶栓治疗方面取得进一步进展。纤维蛋白溶解酶的酰化将产生有益效果（储存效应、免受内源性抑制剂的影响）。由于对具有纤维蛋白溶解和溶栓作用的物质进行了广泛研究，预计会出现新一代纤维蛋白溶解激活剂，它能干扰血管壁纤溶酶原激活物的生物合成和释放，适用于治疗纤维蛋白溶解低下状态。
