Rietbrock N, Fischer A, Menke G
Abteilung für Klinische Pharmakologie des Klinikums der Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.
Z Kardiol. 1987 Oct;76(10):621-5.
Following oral administration of 240 mg Verapamil-HCl as Isoptin RR, Veramex SR 240 and durasoptin SR 240, plasma concentration time curves of Verapamil and ECG changes were determined in 14 healthy subjects. There was a linear correlation between maximal plasma concentration and prolongation of PQ-intervals of the ECG. No hysteresis was observed when the changes in PQ-interval were plotted against plasma concentration. Comparison of concentration and effect profiles showed that the three formulations were not equivalent and a change in therapy from one to the other cannot be recommended.
在14名健康受试者中，口服240毫克盐酸维拉帕米（商品名：异搏定RR、维拉美克缓释片240和度拉索平缓释片240）后，测定了维拉帕米的血浆浓度-时间曲线以及心电图变化。最大血浆浓度与心电图PQ间期延长之间存在线性相关性。当将PQ间期变化与血浆浓度作图时，未观察到滞后现象。浓度和效应曲线的比较表明，这三种制剂不等效，不建议在不同制剂之间更换治疗方案。
