Logie Emilie, Vanden Berghe Wim
Lab Protein Chemistry, Proteomics & Epigenetic Signaling (PPES), Department Biomedical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
Antioxidants (Basel). 2020 Nov 10;9(11):1107. doi: 10.3390/antiox9111107.
Chronic inflammatory diseases are considered to be one of the biggest threats to human health. Most prescribed pharmaceutical drugs aiming to treat these diseases are characterized by side-effects and negatively affect therapy adherence. Finding alternative treatment strategies to tackle chronic inflammation has therefore been gaining interest over the last few decades. In this context, Withaferin A (WA), a natural bioactive compound isolated from has been identified as a promising anti-cancer and anti-inflammatory compound. Although the majority of studies focus on the molecular mechanisms of WA in cancer models, recent evidence demonstrates that WA also holds promise as a new phytotherapeutic agent against chronic inflammatory diseases. By targeting crucial inflammatory pathways, including nuclear factor kappa B (NF-kB) and nuclear factor erythroid 2 related factor 2 (Nrf2) signaling, WA suppresses the inflammatory disease state in several in vitro and preclinical in vivo models of diabetes, obesity, neurodegenerative disorders, cystic fibrosis and osteoarthritis. This review provides a concise overview of the molecular mechanisms by which WA orchestrates its anti-inflammatory effects to restore immune homeostasis.
慢性炎症性疾病被认为是对人类健康的最大威胁之一。大多数用于治疗这些疾病的处方药都有副作用，会对治疗依从性产生负面影响。因此，在过去几十年里，寻找治疗慢性炎症的替代策略越来越受到关注。在这种背景下，从 中分离出的天然生物活性化合物 Withaferin A（WA）已被确定为一种有前景的抗癌和抗炎化合物。尽管大多数研究集中在WA在癌症模型中的分子机制，但最近的证据表明，WA作为一种治疗慢性炎症性疾病的新型植物治疗剂也具有潜力。通过靶向关键的炎症信号通路，包括核因子κB（NF-κB）和核因子红细胞2相关因子2（Nrf2）信号通路，WA在糖尿病、肥胖、神经退行性疾病、囊性纤维化和骨关节炎的几种体外和临床前体内模型中抑制炎症疾病状态。这篇综述简要概述了WA协调其抗炎作用以恢复免疫稳态的分子机制。
