Kaya Abdurrahman, Kaya Sibel Yıldız
Department of Infectious Diseases, İstanbul Training and Research Hospital, Istanbul, Turkey.
Infectious Diseases Unit, Sungurlu State Hospital, Çorum, Turkey.
BMC Gastroenterol. 2020 Nov 12;20(1):379. doi: 10.1186/s12876-020-01496-5.
Syphilis is a sexuality transmitted disease caused by Treponema pallidum. Liver involvement is very rarely seen and occurs in the second phase of the disease. Syphilitic hepatitis generally is mild clinical condition and is characterized by high serum alkaline phosphatase level, often with normal or only slightly abnormal transaminases. The skin eruptions are classically diffuse, symmetric maculopapular rashes involving trunk and extremities. Involvement of palms and soles is a strong clue to the diagnosis of secondary syphilis. Therefore, syphilitic hepatitis should be included in the early differential diagnosis in patient with abnormal liver enzyme, especially increased alkaline phosphatase, and rashes involving palms and soles.
梅毒是一种由梅毒螺旋体引起的性传播疾病。肝脏受累非常罕见，发生在疾病的第二期。梅毒肝炎通常是一种轻度临床病症，其特征是血清碱性磷酸酶水平升高，转氨酶通常正常或仅略有异常。皮疹典型表现为弥漫性、对称性的斑丘疹，累及躯干和四肢。手掌和足底受累是二期梅毒诊断的重要线索。因此，对于肝酶异常，尤其是碱性磷酸酶升高且伴有手掌和足底皮疹的患者，早期鉴别诊断应包括梅毒肝炎。
