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羟基磷灰石复合纳米人工骨在踝关节损伤患者治疗及康复中的作用。

Effect of Hydroxyapatite Composite Nano-Artificial Bone on Treatment and Rehabilitation of Patients with Ankle Joint Injury.

机构信息

Department of Comprehensive Rehabilitation, Orthopedic Hospital of Henan Province, Luoyang, 471002, Henan, China.

Department of Research and Intellectual Property, Orthopedic Hospital of Henan Province, Luoyang, 471002, Henan, China.

出版信息

J Nanosci Nanotechnol. 2021 Feb 1;21(2):1091-1098. doi: 10.1166/jnn.2021.18650.

Abstract

The formation of natural bone tissue is the result of the joint regulation of multiple template molecules. Although its complex hierarchical structure has been studied for many years, the mechanism of biomineralization of hard bone tissue has not been fully clarified. In this paper, the nanocomposites obtained by mineralization were characterized and analyzed, and the effect of the template on the crystal formation of hydroxyapatite was studied. The characterization results show that the main phase of the inorganic mineral obtained by template mineralization is the hydroxyapatite phase. The nano-apatite composite particles with an inorganic component content of 90.2% have the highest loading efficiency, reaching 67.9 mg/g. By statistical analysis of the pain scores at 5 days, 10 days, and 15 days after ankle injury, it was found that the average pain score of the treatment group was smaller than that of the control group. Two weeks later, the clinical efficacy judgment standard statistics show that the treatment group has a 22.5% improvement in healing rate, a significant increase in 3.18%, and a total effective rate of 8.71%, which is significantly better than the control group.

摘要

天然骨组织的形成是多种模板分子共同调控的结果。尽管其复杂的层次结构已经研究了很多年,但硬骨组织的生物矿化机制仍未完全阐明。本文对矿化得到的纳米复合材料进行了表征和分析,并研究了模板对羟基磷灰石晶体形成的影响。表征结果表明,模板矿化得到的无机矿物的主要相为羟基磷灰石相。无机成分含量为 90.2%的纳米磷灰石复合颗粒的负载效率最高,达到 67.9mg/g。通过对踝关节损伤后 5 天、10 天和 15 天疼痛评分的统计分析,发现治疗组的平均疼痛评分小于对照组。2 周后,临床疗效判断标准统计显示,治疗组愈合率提高 22.5%,显著提高 3.18%,总有效率 8.71%,明显优于对照组。

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