State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China.
State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China.
Carbohydr Polym. 2021 Jan 15;252:117155. doi: 10.1016/j.carbpol.2020.117155. Epub 2020 Oct 1.
Inulin-type fructans (ITFs) as functional fructans and soluble dietary fiber are a mixture of inulin, oligofructose and fructooligosaccharide with β configuration. They are modified by gut microbiota at the end of ileum, subsequently, improve digestive system, metabolic syndrome, immune system and inflammatory diseases, and prevent against infection and cancer. However, it has been reported that inadequate consumption of ITFs aggravates the development of non-alcoholic fatty liver disease, results in gastrointestinal symptoms, liver cancer and intestinal inflammation. Therefore, this review summarizes the health benefits, pharmaceutical applications and safety evaluation of ITFs, which would direct their rational applications.
菊粉型果聚糖（ITFs）作为功能性果聚糖和可溶性膳食纤维，是由具有β构型的菊粉、低聚果糖和果寡糖混合而成。它们在回肠末端被肠道微生物群修饰，随后改善消化系统、代谢综合征、免疫系统和炎症性疾病，并预防感染和癌症。然而，据报道，ITFs 的摄入量不足会加重非酒精性脂肪肝疾病的发展，导致胃肠道症状、肝癌和肠道炎症。因此，本综述总结了 ITFs 的健康益处、药物应用和安全性评价，这将指导其合理应用。
