University of South Alabama, College of Allied Health Professions, The Department of Speech Pathology and Audiology, 5721 USA Drive N HAHN 1119, Mobile AL 36688, USA.
University of Tennessee Health Science Center, Department of Audiology and Speech Pathology, 578 South Stadium Hall, UT, Knoxville, TN 37996-0740, USA.
Neurosci Lett. 2021 Jan 1;740:135460. doi: 10.1016/j.neulet.2020.135460. Epub 2020 Oct 24.
To determine whether speech-evoked auditory brainstem response (ABR) is more sensitive to the effects of multiple sclerosis (MS) than click-evoked ABR.
Eleven previously-confirmed MS patients (8 females, 3 males) and nine controls (7 females, 2 males), matched in age and gender, participated in a repeated-measures design. Stimuli were presented monaurally to the right ear via insert earphone. All evoked potential responses were collected by a single-channel montage where three electrodes were placed on the center of the head (Cz: non-inverting/ active), the ipsilateral earlobe (inverting/ reference) and the contralateral earlobe (ground). Rarefaction clicks of 0.1 ms duration were presented at rates of 13.30 and 91.1 clicks per second. Speech-evoked ABRs were obtained using the BioMARK software and the Bio-Logic Navigator PRO hardware. A synthesized /da/ syllable of 40-ms duration was presented via alternating polarity and at a rate of 10.9 stimuli per second. Stimuli were presented at 80 dB SPL. Speech-evoked ABR responses were obtained in quiet and in noise.
Conventional click ABR responses were absent more often at high presentation rates in control subjects than in MS patients. Speech-evoked ABR peak amplitudes, wave E latency and VA complex slope variables separated the MS patients from controls. Group differences were also found in speech-evoked ABR response correlations in quiet versus noise conditions.
The speech-evoked ABR is as or more sensitive to MS than conventional ABR measures without resort to simply noting missing peaks. Comparison of speech-evoked ABR responses in quiet and in noise highlight loss of neural synchrony in MS.
确定语音诱发听觉脑干反应（ABR）是否比click-evoked ABR 更能敏感地反映多发性硬化症（MS）的影响。
11 名先前确诊的 MS 患者（8 名女性，3 名男性）和 9 名对照组（7 名女性，2 名男性），按年龄和性别匹配，参与了重复测量设计。刺激通过插入耳机单侧传至右耳。所有诱发电位反应均通过单通道蒙太奇收集，三个电极放置在头部中央（Cz：非反转/活动）、同侧耳垂（反转/参考）和对侧耳垂（地）。0.1ms 持续时间的稀疏 click 以 13.30 和 91.1 个每秒的速率呈现。使用 BioMARK 软件和 Bio-Logic Navigator PRO 硬件获得语音诱发 ABR。40ms 持续时间的合成 /da/ 音节通过交替极性以 10.9 个每秒的速率呈现。刺激在 80dB SPL 下呈现。在安静和噪声环境中获得语音诱发 ABR 反应。
在对照组中，高呈现率时常规 click ABR 反应更常缺失，而在 MS 患者中则较少。语音诱发 ABR 峰值振幅、波 E 潜伏期和 VA 复合斜率变量将 MS 患者与对照组区分开来。在安静和噪声条件下，语音诱发 ABR 反应的组间差异也存在。
与不依赖于简单地记录缺失峰值的传统 ABR 测量相比，语音诱发 ABR 对 MS 更敏感。在安静和噪声环境下比较语音诱发 ABR 反应，突出了 MS 中神经同步的丧失。
