Università degli Studi di Roma La Sapienza Ortopedia e Traumatologia.
Universita degli Studi di Roma La Sapienza Radiologia.
Handchir Mikrochir Plast Chir. 2021 Aug;53(4):376-382. doi: 10.1055/a-1240-0181. Epub 2020 Nov 12.
Chronic osteomyelitis is a major challenge in orthopaedic surgery; it is the result of open fracture, periprosthetic infection and septic arthritis. Osteomyelitis leads to fracture nonunion. The treatment of bone infection and infected nonunion consists primarily of the complete removal of infected and avascular bone and soft tissue from the surgical site, followed by local and systemic pathogen-specific antibiotic therapy and temporary stabilisation, but may lead to massive skeletal and soft tissue defects. The use of free or pedicled vascularised bone transfers and callus distraction techniques (bone transport) has been recommended for large bone defects. The aim of this study is to evaluate the results of patients affected by infected non-unions of the lower limbs, treated with a corticoperiosteal flap from the medial femoral condyle and to investigate the donor site morbidity of this flap.
The patients were 11 males (average age of 45.6 years), who presented a nonunion of the tibial diaphysis in 7 cases and non-union of femoral diaphysis in 4 cases, treated with free or pedicled corticoperiosteal flap. In all patients, surgical debridement was performed before the flap of infected bone and soft tissues that would not contribute to wound healing. Clinical and radiographic evaluations of the recipient site were performed. Preoperative and postoperative X-ray and MRI scans after the 3-year follow-up of the donor site were performed, in order to observe possible bone restoration and any complications.
The patients reported complete clinical and radiographic bone healing in 90.9 % of cases. As regards donor site, there were no differences between the medial femoral donor condyle compared to the contralateral site, due to complete regeneration of donor site bone. MRI investigation showed complete restoration of the donor site with vascularised bone in all patients.
Our results suggest that the use of bone flaps for the treatment of infected non-unions is an effective procedure, that must be performed after accurate debridement of the non-union site. The corticoperiosteal flap seems to have few morbidities on the donor site and a high percentage of successful bone healing.
慢性骨髓炎是骨科的一大挑战;它是开放性骨折、假体周围感染和化脓性关节炎的结果。骨髓炎可导致骨折不愈合。骨感染和感染性骨不愈合的治疗主要包括从手术部位彻底清除感染性和无血管性骨和软组织,然后进行局部和全身针对病原体的抗生素治疗以及临时稳定,但可能导致大量的骨骼和软组织缺损。游离或带蒂血运重建骨转移和骨痂牵张技术(骨搬运)已被推荐用于治疗大骨缺损。本研究旨在评估采用股骨内侧髁骨-骨膜瓣治疗下肢感染性骨不连患者的结果,并探讨该皮瓣供区的发病率。
患者为 11 名男性(平均年龄 45.6 岁),7 例胫骨骨干骨不连,4 例股骨骨干骨不连,采用游离或带蒂骨-骨膜瓣治疗。所有患者均在皮瓣感染性骨和软组织切除前进行手术清创,这些组织不会促进伤口愈合。对受区进行临床和影像学评估。对供区进行术前和术后 X 线和 MRI 扫描,并在 3 年随访后进行,以观察可能的骨重建和任何并发症。
90.9%的患者报告完全临床和影像学骨愈合。就供区而言,由于供区骨完全再生,内侧股骨供区髁与对侧相比无差异。MRI 检查显示所有患者供区均有血管化骨完全恢复。
我们的结果表明,使用骨瓣治疗感染性骨不连是一种有效的方法,必须在准确清创骨不连部位后进行。皮质骨-骨膜瓣似乎对供区的并发症较少,且有较高的骨愈合成功率。