Department of Materials Science and Metallurgical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Kandi, Telangana, 502285, India.
School of Engineering, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Victoria, Hawthorn, 3122, Australia.
Small. 2020 Dec;16(49):e2004900. doi: 10.1002/smll.202004900. Epub 2020 Nov 13.
2D nanomaterials (2DNMs) possess fascinating properties and are found in multifarious devices and applications including energy storage devices, new generation of battery technologies, sensor devices, and more recently in biomedical applications. Their use in biomedical applications such as tissue engineering, photothermal therapy, neural regeneration, and drug delivery has opened new horizons in treatment of age-old ailments. It is also a rapidly developing area of advanced research. A new approach of integrating 3D printing (3DP), a layer-by-layer deposition technique for building structures, along with 2DNM multifunctional inks, has gained considerable attention in recent times, especially in biomedical applications. With the ever-growing demand in healthcare industry for novel, efficient, and rapid technologies for therapeutic treatment methods, 3DP structures of 2DNMs provide vast scope for evolution of a new generation of biomedical devices. Recent advances in 3DP structures of dispersed 2DNM inks with established high-performance biomedical properties are focused on. The advantages of their 3D structures, the sustainable formulation methods of such inks, and their feasible printing methods are also covered. Subsequently, it deals with the therapeutic applications of some already researched 3DP structures of 2DNMs and concludes with highlighting the challenges as well as the future directions of research in this area.
二维纳米材料（2DNMs）具有迷人的性质，广泛应用于各种设备和领域，包括储能设备、新一代电池技术、传感器设备等，最近在生物医学应用中也得到了广泛应用。它们在生物医学应用中的应用，如组织工程、光热治疗、神经再生和药物输送，为治疗古老疾病开辟了新的前景。这也是一个快速发展的高级研究领域。一种新的方法是将 3D 打印（3DP）与 2DNM 多功能墨水相结合，3DP 是一种逐层沉积技术，用于构建结构，这种方法在最近引起了相当大的关注，尤其是在生物医学应用中。随着医疗保健行业对新型、高效和快速治疗方法的需求不断增长，2DNM 的 3DP 结构为新一代生物医学设备的发展提供了广阔的空间。本文重点介绍了分散在具有既定高性能生物医学特性的 2DNM 油墨中的 3DP 结构的最新进展。讨论了它们的 3D 结构优势、可持续的油墨配方方法和可行的打印方法。随后，介绍了一些已经研究过的 2DNM 的 3DP 结构的治疗应用，并总结了该领域研究的挑战和未来方向。
