Zhang Liwen, Forgham Helen, Shen Ao, Wang Jiafan, Zhu Jiayuan, Huang Xumin, Tang Shi-Yang, Xu Chun, Davis Thomas P, Qiao Ruirui
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
J Mater Chem B. 2022 Sep 28;10(37):7473-7490. doi: 10.1039/d2tb00931e.
3D printing technology, otherwise known as additive manufacturing, has provided a promising tool for manufacturing customized biomaterials for tissue engineering and regenerative medicine applications. A vast variety of biomaterials including metals, ceramics, polymers, and composites are currently being used as base materials in 3D printing. In recent years, nanomaterials have been incorporated into 3D printing polymers to fabricate innovative, versatile, multifunctional hybrid materials that can be used in many different applications within the biomedical field. This review focuses on recent advances in novel hybrid biomaterials composed of nanomaterials and 3D printing technologies for biomedical applications. Various nanomaterials including metal-based nanomaterials, metal-organic frameworks, upconversion nanoparticles, and lipid-based nanoparticles used for 3D printing are presented, with a summary of the mechanisms, functional properties, advantages, disadvantages, and applications in biomedical 3D printing. To finish, this review offers a perspective and discusses the challenges facing the further development of nanomaterials in biomedical 3D printing.
3D打印技术，又称增材制造，为制造用于组织工程和再生医学应用的定制生物材料提供了一种很有前景的工具。目前，包括金属、陶瓷、聚合物和复合材料在内的各种各样的生物材料正被用作3D打印的基础材料。近年来，纳米材料已被纳入3D打印聚合物中，以制造创新、通用、多功能的混合材料，这些材料可用于生物医学领域的许多不同应用。本综述重点关注由纳米材料和3D打印技术组成的新型混合生物材料在生物医学应用方面的最新进展。介绍了用于3D打印的各种纳米材料，包括金属基纳米材料、金属有机框架、上转换纳米颗粒和脂质基纳米颗粒，并总结了其在生物医学3D打印中的作用机制、功能特性、优点、缺点及应用。最后，本综述提供了一个观点，并讨论了纳米材料在生物医学3D打印进一步发展中面临的挑战。
