Vignan's Foundation for Science, Technology and Research-VFSTR (Deemed to be University), Vadlamudi, Guntur 522 213, Andhra Pradesh, India.
Bapatla engineering college, Bapatla, Andhra Pradesh, India.
Mini Rev Med Chem. 2021;21(6):704-723. doi: 10.2174/1389557520666201113105940.
The current pandemic of COVID-19 caused by SARS-Cov-2 has posed a severe threat to the whole world with its highly infectious, progressive nature with up to 10% mortality rates. The severity of the situation faced by the whole world and the lack of efficient therapeutics to treat this viral disease have led the WHO to depend on the drug-repurposing approach to tackle this major global health problem. This review aims at highlighting the various synthetic approaches employed for the synthesis of these FDA approved drugs that have been presently used for COVID-19 treatment. Additionally, a brief overview of several therapeutic strategies is also presented. This review will encourage the scientific community across the globe to come up with better and efficient synthetic protocols and also novel chemical entities along with this core with more potent activity.
由 SARS-CoV-2 引起的当前 COVID-19 大流行，其高传染性和渐进性特征对全球构成了严重威胁，死亡率高达 10%。全球面临的局势的严峻性以及缺乏有效的治疗这种病毒性疾病的药物，导致世卫组织依赖于药物再利用的方法来解决这一重大的全球健康问题。本综述旨在强调为合成这些已被批准用于 COVID-19 治疗的药物而采用的各种合成方法。此外，还简要介绍了几种治疗策略。本综述将鼓励全球科学界提出更好、更有效的合成方案以及具有更强活性的新型化学实体。
