Igarashi I, Oo M M, Stanley H, Reese R, Aikawa M
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
Am J Trop Med Hyg. 1987 Nov;37(3):511-5. doi: 10.4269/ajtmh.1987.37.511.
Plasmodium falciparum-infected erythrocytes attach to the endothelial cells via electron-dense knobs and this attachment has been suggested as one of the contributing factors in the development of cerebral malaria. Monoclonal antibodies against an 80-95 Kd knob protein were prepared and applied to brain tissue from cerebral malaria patients. The deposition of the 80-95 Kd knob protein antibodies was observed in the basement membrane of cerebral capillaries by the peroxidase anti-peroxidase method. This result indicates involvement of knob protein deposition in the pathogenesis of cerebral malaria.
恶性疟原虫感染的红细胞通过电子致密的凸起附着在内皮细胞上，这种附着被认为是导致脑型疟疾的因素之一。制备了针对80-95 Kd凸起蛋白的单克隆抗体，并将其应用于脑型疟疾患者的脑组织。通过过氧化物酶抗过氧化物酶方法在脑毛细血管基底膜中观察到80-95 Kd凸起蛋白抗体的沉积。这一结果表明凸起蛋白沉积参与了脑型疟疾的发病机制。
