Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Drug Dev Ind Pharm. 2020 Dec;46(12):2105-2110. doi: 10.1080/03639045.2020.1851245. Epub 2020 Nov 23.
Cancer is the disease of this era. Its therapy is moving through ups and downs not only due to poor effectiveness of many treating drugs, but also due to the serious side effects always evolving. In an attempt to overcome this problem, many systems, including lipid-based carriers, have been exploited for their oral delivery. Throughout this study, the meta-analysis tool was used to combine data from different studies and extract evidences that lipid-based carriers enhance the oral bioavailability. Consequently, increasing the efficiency and the reduction in side effects of drugs would follow. Accordingly, the usual parameter to indicate the bioavailability; the area under effect curve (AUC) was used where the lipid carriers have proven their superiority over conventional formulations. Interestingly, by comparing microemulsion/self-microemulsifying system (SMEDDS) versus liposomes/pro-liposomes as subgroups of the meta-analysis study, insignificant differences were recorded between them.
癌症是这个时代的疾病。它的治疗方法不断起伏，不仅因为许多治疗药物效果不佳，还因为不断出现严重的副作用。为了克服这个问题，许多系统，包括基于脂质的载体，都被用于口服给药。在整个研究过程中，使用荟萃分析工具将来自不同研究的数据合并，并提取证据表明基于脂质的载体可以提高口服生物利用度。因此，药物的效率会提高，副作用会减少。因此，通常用于表示生物利用度的参数是药时曲线下面积（AUC），其中脂质载体已被证明优于传统制剂。有趣的是，通过比较微乳液/自微乳系统（SMEDDS）与脂质体/前脂质体作为荟萃分析研究的亚组，它们之间没有记录到显著差异。
