Determination of local flow ratios and velocities in a femoral venous cannula with computational fluid dynamics and 4D flow-sensitive magnetic resonance imaging: A method validation.

Cannulas with multi-staged side holes are the method of choice for femoral cannulation in extracorporeal therapies today. A variety of differently designed products is available on the market. While the preferred tool for the performance assessment of such cannulas are pressure-flow curves, little is known about the flow and velocity distribution. Within this work flow and velocity patterns of a femoral venous cannula with multi-staged side holes were investigated. A mock circulation loop for cannula performance evaluation was built and reproduced using a computer-aided design system. With computational fluid dynamics, volume flows and fluid velocities were determined quantitatively and visually with hole-based precision. In order to ensure the correctness of the flow simulation, the results were subsequently validated by determining the same parameters with four-dimensional flow-sensitive magnetic resonance imaging. Measurement data and numerical solution differed 7% on average throughout the data set for the examined parameters. The highest inflow and velocity were detected at the most proximal holes, where half of the total volume flow enters the cannula. At every hole stage a Y-shaped inflow profile was detected, forming a centered stream in the middle of the cannula. Simultaneously, flow separation creates zones with significant lower flow velocities. Numerical simulation, validated with four-dimensional flow-sensitive magnetic resonance imaging, is a valuable tool to examine flow and velocity distributions of femoral venous cannulas with hole-based accuracy. Flow and velocity distribution in such cannulas are not ideal. Based on this work future cannulas can be effectively optimized.