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轴流泵锥形弯形入口插管对血栓形成的影响：一项实验与模拟研究

Effects of Cone-Shaped Bend Inlet Cannulas of an Axial Blood Pump on Thrombus Formation: An Experiment and Simulation Study.

作者信息

Liu Guangmao, Zhou Jianye, Sun Hansong, Zhang Yan, Chen Haibo, Hu Shengshou

机构信息

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Beijing, China (mainland).

出版信息

Med Sci Monit. 2017 Apr 5;23:1655-1661. doi: 10.12659/msm.903421.

DOI:10.12659/msm.903421
PMID:28379938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5389533/
Abstract

BACKGROUND Cannula shape and connection style influence the risk of thrombus formation in the blood pump by varying the blood flow characteristics inside the pump. Inlet cannulas should be designed based on the need for anatomical fit and reducing the risk of thrombus generation in the blood pump. The effects on thrombus formation of the cone-shaped bend inlet cannulas of axial blood pumps should be studied. MATERIAL AND METHODS The cannulas were designed as cone-shaped, with 1 bent section connecting 2 straight sections. Both the silicone tube and novel cone-shaped cannula were simulated for comparison. The flow fields of a blood pump with inlet cannula were simulated by computational fluid dynamics (CFD) at flows of 2.0, 2.5, and 3.0 liters per minute (lpm), with pump rotational speeds of 7500, 8000, and 8500 rpm, respectively. Then, 6 two-dimensional (2D) particle image velocimetry (PIV) tests were conducted and the velocity distributions were analyzed. RESULTS A low-velocity region was located inside the pump entrance when a soft silicone tube was used. At 8500 rpm and 3.0 lpm working condition, the minimum velocity inside the pump with cone-shaped cannulas was 2.5×10^-1 m/s. The cone-shaped cannulas eliminated the low-velocity region inside the pump. Both CFD and PIV results showed that the low-velocity region did not spread to the entrance of the blood pump within the flow range from 2.0 lpm to 7.0 lpm. CONCLUSIONS The designed cone-shaped bent cannulas can eliminate the low-velocity region inside the blood pump and reduce the risk of thrombus formation in the blood pump.

摘要

背景

插管形状和连接方式会通过改变血泵内部的血流特性来影响血栓形成的风险。入口插管应根据解剖适配需求和降低血泵内血栓形成风险来进行设计。应研究轴流血泵的锥形弯管入口插管对血栓形成的影响。

材料与方法

插管设计为锥形，有1个弯曲部分连接2个直管部分。对硅胶管和新型锥形插管都进行了模拟以作比较。通过计算流体动力学（CFD）在每分钟2.0、2.5和3.0升（lpm）的流量下，分别对应泵转速为7500、8000和8500转/分钟（rpm）时，模拟了带有入口插管的血泵的流场。然后，进行了6次二维（2D）粒子图像测速（PIV）测试并分析了速度分布。

结果

当使用软硅胶管时，泵入口内部存在一个低速区域。在8500 rpm和3.0 lpm的工作条件下，带有锥形插管的泵内部的最小速度为2.5×10^-1米/秒。锥形插管消除了泵内部的低速区域。CFD和PIV结果均表明，在2.0 lpm至7.0 lpm的流量范围内，低速区域未扩散到血泵入口。

结论

设计的锥形弯管插管可消除血泵内部的低速区域并降低血泵内血栓形成的风险。

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