From the Department of Radiology, The First Hospital of China Medical University, Liaoning, PR China.
J Comput Assist Tomogr. 2021;45(1):98-102. doi: 10.1097/RCT.0000000000001111.
A limited number of studies have used the intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) approach on bone marrow. The purpose of this study was to qualitatively and quantitatively compare the clinical value of IVIM based on field-of-view optimized and constrained undistorted single shot (FOCUS) with the standard single-shot echo-planar imaging (ss-EPI) in the vertebral bone marrow.
Twenty healthy volunteers underwent ss-EPI and FOCUS IVIM-DWI of the lumbar spine. Intravoxel incoherent motion parameters (the apparent diffusion coefficient [ADC], true diffusion coefficient [D], pseudodiffusion coefficient [D*], and perfusion fraction [f]) were calculated.
The FOCUS IVIM protocol allowed for measurement of ADC, D, D*, and f in all volunteers: ADC, 0.28 ± 1.33 ×10-3 mm2/s; D = 0.25 ± 3.98 ×10-3 mm2/s, f = 0.36 ± 4.01; and D* = 102.16 ± 71.21 ×10-3 mm2/s. There were no significant differences between the values of ADC, D, and f obtained with ss-EPI and FOCUS. The D* was significantly different (P < 0.05) between ss-EPI and FOCUS IVIM. Image quality assessments showed that the image qualities of FOCUS were superior to ss-EPI (P < 0.001).
As a high-resolution IVIM-DWI technique, the FOCUS technique has potential clinical utility in evaluating the diffusion and perfusion in the vertebral bone marrow.
少数研究曾在骨髓中使用体素内不相干运动（IVIM）扩散加权成像（DWI）方法。本研究旨在定性和定量比较基于视野优化和无扭曲单次激发（FOCUS）的 IVIM 与标准单次激发回波平面成像（ss-EPI）在椎骨骨髓中的临床价值。
20 名健康志愿者接受了 ss-EPI 和 FOCUS IVIM-DWI 腰椎检查。计算体素内不相干运动参数（表观扩散系数[ADC]、真实扩散系数[D]、假性扩散系数[D*]和灌注分数[f]）。
FOCUS IVIM 方案可在所有志愿者中测量 ADC、D、D和 f：ADC 为 0.28 ± 1.33×10-3mm2/s；D=0.25 ± 3.98×10-3mm2/s，f=0.36 ± 4.01；D=102.16 ± 71.21×10-3mm2/s。ss-EPI 和 FOCUS 获得的 ADC、D 和 f 值之间无显著差异。D*在 ss-EPI 和 FOCUS IVIM 之间有显著差异（P<0.05）。图像质量评估显示 FOCUS 的图像质量优于 ss-EPI（P<0.001）。
作为一种高分辨率 IVIM-DWI 技术，FOCUS 技术在评估椎骨骨髓中的扩散和灌注方面具有潜在的临床应用价值。
