Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Int Immunopharmacol. 2021 Jan;90:107158. doi: 10.1016/j.intimp.2020.107158. Epub 2020 Nov 10.
Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes, neutrophils, and macrophages and was initially introduced as anti-cancer agent. However, in some cases, it promotes cancer progression. Overexpression of OSM and OSM receptor has been detected in various cancers including colon cancer, breast cancer, pancreatic cancer, myeloma, brain tumors, chronic lymphocytic leukemia, and hepatoblastoma. STAT3 is the main downstream signaling molecule of OSM, which operates the leading role in modifications of cancer cells and enhancing cell growth, invasion, survival, and all other hallmarks of cancer cells. However, due to the presence of multiple signaling pathways, it can act contradictory in some cancers. In this review, we will discuss the emerging roles of OSM in cancer and elucidate its function in tumor control or progression and finally discuss therapeutic approaches designed to manipulate this cytokine in cancer.
肿瘤坏死因子 M（OSM）作为白细胞介素-6 家族细胞因子的一员，在炎症、自身免疫和癌症中发挥着重要作用。它主要由 T 淋巴细胞、中性粒细胞和巨噬细胞分泌，最初被引入作为抗癌剂。然而，在某些情况下，它促进了癌症的进展。在包括结肠癌、乳腺癌、胰腺癌、骨髓瘤、脑肿瘤、慢性淋巴细胞白血病和肝母细胞瘤在内的各种癌症中，都检测到了 OSM 和 OSM 受体的过度表达。STAT3 是 OSM 的主要下游信号分子，它在癌细胞的修饰和增强细胞生长、侵袭、存活以及癌细胞的所有其他特征中发挥着主导作用。然而，由于存在多种信号通路，它在某些癌症中可能会产生相反的作用。在这篇综述中，我们将讨论 OSM 在癌症中的新作用，并阐明其在肿瘤控制或进展中的功能，最后讨论旨在操纵这种细胞因子在癌症中的治疗方法。
