Department of Chemistry, Indian Institute of Technology Guwahati, 781039 Assam, India.
Dalton Trans. 2020 Dec 8;49(46):16928-16934. doi: 10.1039/d0dt02323j.
A 3D metal-organic framework (MOF) called Al-DUT-5-N2H3 (1) (DUT: Dresden University of Technology) was prepared hydrothermally using Al(iii) salt and a hydrazinyl functionalized linker called 2-hydrazinyl-[1,1'-biphenyl]-4,4'-dicarboxylic acid (BPDC-N2H3). Material 1 was successfully characterized by X-ray powder diffraction (XRPD), FT-IR spectroscopy, N2 sorption (BET) experiment, thermogravimetric analysis (TGA), EDX and FE-SEM analyses. The activated form of material 1 (called 1') was achieved by a direct heating process. Material 1' was successfully employed for the solution-phase fluorescence detection of α-ketoglutaric acid (α-KG). It showed high detection performance even when there were other competitive analytes present in the mixture. Material 1' is the first MOF-based fluorescent turn-off sensor for the detection of α-KG. The response time for α-KG is exceptionally low (60 s) as compared to any other reported α-KG sensor. The limit of detection (LOD) was found to be 0.61 μM, which is far better as compared to any other reported sensor for α-KG to date. The mechanism for α-KG sensing was thoroughly investigated and proposed to be PET (photoinduced electron transfer) process by TD-DFT (time-dependent DFT) calculations.
一种称为 Al-DUT-5-N2H3（1）（DUT：德累斯顿工业大学）的三维金属有机骨架（MOF）是通过水热法使用 Al（iii）盐和一种称为 2-肼基-[1,1'-联苯]-4,4'-二羧酸（BPDC-N2H3）的肼基功能化连接体制备的。材料 1 通过 X 射线粉末衍射（XRPD）、FT-IR 光谱、N2 吸附（BET）实验、热重分析（TGA）、EDX 和 FE-SEM 分析得到了成功的表征。材料 1 的激活形式（称为 1'）是通过直接加热过程实现的。材料 1'成功地用于α-酮戊二酸（α-KG）的溶液相荧光检测。即使在混合物中存在其他竞争分析物，它也表现出高检测性能。材料 1'是用于检测α-KG 的第一个基于 MOF 的荧光关闭传感器。与任何其他报道的α-KG 传感器相比，α-KG 的响应时间非常短（60 s）。检测限（LOD）被发现为 0.61 μM，与迄今为止报道的任何其他α-KG 传感器相比，这要好得多。对α-KG 传感的机制进行了彻底的研究，并通过 TD-DFT（时间相关的 DFT）计算提出了 PET（光诱导电子转移）过程。
