Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Brazilian Bioscience National Laboratory, Brazil Center of Research in Energy and Materials, Campinas, Brazil.
Oral Dis. 2022 Mar;28(2):326-335. doi: 10.1111/odi.13716. Epub 2020 Dec 3.
Osteopontin (OPN) is a calcium-binding glycol-phosphoprotein present in many physiologic and pathological processes. This protein can control bone cell adhesion, osteoclastic activity, and bone matrix mineralization. However, its participation in pathological processes such as atherosclerosis, sarcoidosis, tuberculosis, and cancer have been described. Some studies have shown that OPN may participate in the development and progression of oral cancer. Although the role of OPN in oral cancer is not fully understood, some studies have suggested that this protein may induce malignant phenotype of cells by activation of PI3K/AKT/mTOR pathway, which favors cell proliferation, invasion, metastasis, angiogenesis, and failure of treatment. This review discusses the possible mechanism of involvement of OPN in oral cancer and its potential clinical application in diagnosis and prognosis.
骨桥蛋白（OPN）是一种存在于许多生理和病理过程中的钙结合糖磷蛋白。该蛋白可控制骨细胞黏附、破骨细胞活性和骨基质矿化。然而，其在动脉粥样硬化、结节病、结核病和癌症等病理过程中的参与作用已被描述。一些研究表明，OPN 可能参与口腔癌的发生和发展。尽管 OPN 在口腔癌中的作用尚未完全阐明，但一些研究表明，该蛋白可能通过激活 PI3K/AKT/mTOR 通路诱导细胞的恶性表型，从而促进细胞增殖、侵袭、转移、血管生成和治疗失败。本综述讨论了 OPN 参与口腔癌的可能机制及其在诊断和预后方面的潜在临床应用。
