Morphological transformation and tumorigenicity in C3H/10T1/2 cells transformed with an inducible c-Ha-ras oncogene.
作者信息
Trimble W S, Boulianne G L, Hozumi N
机构信息
Department of Medical Genetics, University of Toronto, Ontario, Canada.
出版信息
Biosci Rep. 1987 Jul;7(7):579-85. doi: 10.1007/BF01119775.
PMID:3318947
Abstract
A C3H/10T1/2 cell line containing an inducible metallothionein-ras hybrid oncogene was conditionally and reversibly transformed upon exposure to zinc ions. Interestingly, although the cell line was fully malignant when expressing only low levels of ras, complete morphological transformation required much higher levels.
摘要
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