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用可诱导的c-Ha-ras癌基因转化的C3H/10T1/2细胞中的形态学转变和致瘤性

Morphological transformation and tumorigenicity in C3H/10T1/2 cells transformed with an inducible c-Ha-ras oncogene.

作者信息

Trimble W S, Boulianne G L, Hozumi N

机构信息

Department of Medical Genetics, University of Toronto, Ontario, Canada.

出版信息

Biosci Rep. 1987 Jul;7(7):579-85. doi: 10.1007/BF01119775.

DOI:10.1007/BF01119775
PMID:3318947
Abstract

A C3H/10T1/2 cell line containing an inducible metallothionein-ras hybrid oncogene was conditionally and reversibly transformed upon exposure to zinc ions. Interestingly, although the cell line was fully malignant when expressing only low levels of ras, complete morphological transformation required much higher levels.

摘要

一个含有可诱导金属硫蛋白 - ras 杂交癌基因的 C3H/10T1/2 细胞系在暴露于锌离子时会发生条件性和可逆性转化。有趣的是，尽管该细胞系在仅表达低水平 ras 时就完全具有恶性，但完全的形态转化需要更高的水平。

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