Department of Otorhinolaryngology, Hamidiye Medical School, Sultan II. Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Department of Pathology, Sultan II. Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Oral Oncol. 2021 Mar;114:105089. doi: 10.1016/j.oraloncology.2020.105089. Epub 2020 Nov 12.
It is well known that head and neck squamous cell carcinomas are characterized by genetic alterations, genomic instability and different immune defects and Telomerase reverse transcriptase promoter mutations have been found with high rates in patients with tongue squamous cell carcinomas. We presented a non-smoker, no alcohol consuming woman who had a second primary tongue SCC after four and a half years later of her first tongue SCC with TERT promoter mutation. The primary tumor and its recurrences in woman with tongue SCC who have never smoked and had no alcohol consumption may need to be differing from other tongue carcinomas. TERT promoter mutations may have a relation in etiopathogenesis of tumor and mutations need to be on mind in future studies.
众所周知，头颈部鳞状细胞癌的特征是遗传改变、基因组不稳定性和不同的免疫缺陷，端粒酶逆转录酶启动子突变在舌鳞状细胞癌患者中发现率很高。我们报告了一例非吸烟、不饮酒的女性，她在首次舌鳞癌四年半后再次发生第二原发舌鳞癌，且存在 TERT 启动子突变。从未吸烟和饮酒的舌鳞癌女性中，其原发性肿瘤及其复发可能与其他舌癌不同。TERT 启动子突变可能与肿瘤的病因发病机制有关，在未来的研究中需要考虑这些突变。
