成功治疗 15 岁女孩非妊娠性绒癌：病例报告。

Successful Treatment of Nongestational Choriocarcinoma in a 15-Year-Old Girl: A Case Report.

机构信息

Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea.

出版信息

J Pediatr Adolesc Gynecol. 2021 Apr;34(2):231-233. doi: 10.1016/j.jpag.2020.11.004. Epub 2020 Nov 13.

DOI:10.1016/j.jpag.2020.11.004

PMID:33189896

Abstract

BACKGROUND

Nongestational choriocarcinoma is a rare ovarian malignancy with a prognosis worse than that of gestational choriocarcinoma. Debulking surgery is the primary treatment for ovarian carcinoma. However, fertility preservation is important in young women.

CASE

A 15-year-old girl with no sexual experience was admitted for abnormal uterine bleeding. Ultrasonography showed a solid mass in the right ovary and her serum β-human chorionic gonadotrophin levels were markedly elevated. We performed right oophorectomy, omentectomy, and peritoneal washing cytology. The uterus and left adnexa were preserved. She was diagnosed with nongestational choriocarcinoma, stage IIA. She received adjuvant chemotherapy (etoposide, methotrexate, actinomycin, cyclophosphamide, and oncovin regimen) and has been disease-free for more than 5 years.

SUMMARY AND CONCLUSION

Fertility-sparing surgery combined with chemotherapy is an acceptable treatment option for young patients with locally advanced nongestational choriocarcinoma.

摘要

背景

非妊娠性绒癌是一种罕见的卵巢恶性肿瘤，其预后比妊娠性绒癌差。肿瘤细胞减灭术是卵巢癌的主要治疗方法。然而，对于年轻女性来说，保留生育能力很重要。

病例介绍

一名 15 岁、无性生活史的女孩因异常子宫出血就诊。超声检查显示右侧卵巢有实性肿块，血清β-人绒毛膜促性腺激素水平显著升高。我们进行了右侧卵巢切除术、网膜切除术和腹腔灌洗细胞学检查。子宫和左侧附件得以保留。她被诊断为非妊娠性绒癌，ⅡA 期。她接受了辅助化疗（依托泊苷、甲氨蝶呤、放线菌素、环磷酰胺和长春新碱方案），至今已无病生存超过 5 年。