TAPP1 Represses the Differentiation of Oligodendrocyte and its Deficiency Accelerates Myelin Regeneration after Demyelinating Injuries.
作者信息
Mei Ruyi, Fu Jiaying, Jiang Chunxia, Yang Junlin, Zheng Kang, Yang Aifen, Qiu Mengsheng, Zhao Xiaofeng
机构信息
Institute of Developmental and Regenerative Biology, Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 310036, China.
The College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.
出版信息
Neurosci Bull. 2021 Mar;37(3):385-388. doi: 10.1007/s12264-020-00609-0. Epub 2020 Nov 15.
Abstract
摘要
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TAPP1 Represses the Differentiation of Oligodendrocyte and its Deficiency Accelerates Myelin Regeneration after Demyelinating Injuries.TAPP1抑制少突胶质细胞分化，其缺陷可加速脱髓鞘损伤后的髓鞘再生。
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本文引用的文献
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Transcriptional control of myelination and remyelination.髓鞘形成和再髓鞘化的转录控制。
Glia. 2019 Nov;67(11):2153-2165. doi: 10.1002/glia.23636. Epub 2019 Apr 30.
2
A gene regulatory architecture that controls region-independent dynamics of oligodendrocyte differentiation.一种控制少突胶质细胞分化区域独立性动态的基因调控结构。
Glia. 2019 May;67(5):825-843. doi: 10.1002/glia.23569. Epub 2019 Feb 7.
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Regenerating CNS myelin - from mechanisms to experimental medicines.中枢神经系统髓鞘再生——从机制到实验药物。
Nat Rev Neurosci. 2017 Nov 16;18(12):753-769. doi: 10.1038/nrn.2017.136.
4
TAPP1 inhibits the differentiation of oligodendrocyte precursor cells via suppressing the Mek/Erk pathway.TAPP1通过抑制Mek/Erk信号通路来抑制少突胶质细胞前体细胞的分化。
Neurosci Bull. 2015 Oct;31(5):517-26. doi: 10.1007/s12264-015-1537-5. Epub 2015 Aug 4.
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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.基于药物的内源性干细胞调节促进体内功能性髓鞘再生。
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IL-17A activates ERK1/2 and enhances differentiation of oligodendrocyte progenitor cells.白细胞介素-17A激活细胞外信号调节激酶1/2并增强少突胶质细胞祖细胞的分化。
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Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives.少突胶质细胞分化时间的调控：机制与展望。
Neurosci Bull. 2013 Apr;29(2):155-64. doi: 10.1007/s12264-013-1314-2. Epub 2013 Feb 28.
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Rolipram promotes remyelination possibly via MEK-ERK signal pathway in cuprizone-induced demyelination mouse.罗利普兰可能通过 MEK-ERK 信号通路促进髓鞘再形成在 Cuprizone 诱导的脱髓鞘小鼠中。
Exp Neurol. 2012 Oct;237(2):304-11. doi: 10.1016/j.expneurol.2012.07.011. Epub 2012 Jul 24.
9
Gene induction in mature oligodendrocytes with a PLP-tTA mouse line.使用PLP - tTA小鼠品系在成熟少突胶质细胞中进行基因诱导。
Genesis. 2012 May;50(5):424-8. doi: 10.1002/dvg.20808. Epub 2011 Dec 27.
10
Cells of the oligodendroglial lineage, myelination, and remyelination.少突胶质细胞谱系的细胞、髓鞘形成和髓鞘再生。
Biochim Biophys Acta. 2011 Feb;1812(2):184-93. doi: 10.1016/j.bbadis.2010.09.010. Epub 2010 Sep 29.
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