癌症患者的传染病并发症。
Infectious Disease Complications in Patients with Cancer.
机构信息
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Vaccine and Infectious Disease Division, Fred Hutchison Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA, USA.
出版信息
Crit Care Clin. 2021 Jan;37(1):69-84. doi: 10.1016/j.ccc.2020.09.001. Epub 2020 Nov 1.
Abstract
Critically ill patients with cancer are vulnerable to infections because of the underlying malignancy, tumor-directed therapy, immunosuppression, breaches in mucosa or skin, malnutrition, and other factors. Neutropenia remains the most important risk factor for infection. Infectious complications occurring in critically ill patients with cancer can affect the bloodstream, lungs, gastrointestinal tract, central nervous system, urinary tract, and the skin. Pneumonias are the leading cause of infection in patients with cancer admitted to the intensive care unit. Consideration of opportunistic pathogens in the differential diagnosis is important in patients with impaired cellular and/or humoral immunity or compromised splenic function.
摘要
癌症重症患者由于基础恶性肿瘤、肿瘤靶向治疗、免疫抑制、黏膜或皮肤破损、营养不良和其他因素而易发生感染。中性粒细胞减少仍然是感染的最重要危险因素。癌症重症患者发生的感染性并发症可影响血液、肺部、胃肠道、中枢神经系统、尿路和皮肤。肺炎是入住重症监护病房的癌症患者感染的主要原因。对于细胞和/或体液免疫受损或脾脏功能受损的患者，在鉴别诊断中考虑机会性病原体很重要。
相似文献
1
Infectious Disease Complications in Patients with Cancer.癌症患者的传染病并发症。
Crit Care Clin. 2021 Jan;37(1):69-84. doi: 10.1016/j.ccc.2020.09.001. Epub 2020 Nov 1.
2
Sepsis-Associated Outcomes in Critically Ill Patients with Malignancies.恶性肿瘤危重症患者脓毒症相关结局。
Ann Am Thorac Soc. 2015 Aug;12(8):1185-92. doi: 10.1513/AnnalsATS.201501-046OC.
3
Hospital-Acquired Infections in Critically Ill Patients With Cancer.癌症重症患者的医院获得性感染。
J Intensive Care Med. 2019 Jul;34(7):523-536. doi: 10.1177/0885066618788019. Epub 2018 Jul 16.
4
Antibiotic treatment duration for bloodstream infections in critically ill children-A survey of pediatric infectious diseases and critical care clinicians for clinical equipoise.重症患儿血流感染的抗生素治疗疗程——儿科传染病和重症监护临床医生对临床均衡的调查。
PLoS One. 2022 Jul 26;17(7):e0272021. doi: 10.1371/journal.pone.0272021. eCollection 2022.
5
Feeding the critically ill obese patient: a systematic review protocol.为危重症肥胖患者提供营养支持：一项系统评价方案
JBI Database System Rev Implement Rep. 2015 Oct;13(10):95-109. doi: 10.11124/jbisrir-2015-2458.
6
[Respiratory infections caused by Aspergillus spp. in critically ill patients admitted to the intensive care units].[重症监护病房收治的重症患者中曲霉菌属引起的呼吸道感染]
Med Intensiva. 2015 Apr;39(3):149-59. doi: 10.1016/j.medin.2014.02.004. Epub 2014 Apr 6.
7
[Invasive candidiasis in the critically ill, patient non-neutropenic].[重症非中性粒细胞减少患者的侵袭性念珠菌病]
Wien Med Wochenschr. 2007;157(19-20):490-2. doi: 10.1007/s10354-007-0464-0.
8
ICU-acquired infections in immunocompromised patients.免疫功能低下患者 ICU 获得性感染。
Intensive Care Med. 2024 Mar;50(3):332-349. doi: 10.1007/s00134-023-07295-2. Epub 2024 Jan 10.
9
Bloodstream infection caused by extensively drug-resistant Acinetobacter baumannii in cancer patients: high mortality associated with delayed treatment rather than with the degree of neutropenia.癌症患者中广泛耐药鲍曼不动杆菌引起的血流感染：延迟治疗与中性粒细胞减少的程度无关，而与高死亡率相关。
Clin Microbiol Infect. 2016 Apr;22(4):352-358. doi: 10.1016/j.cmi.2015.12.010. Epub 2015 Dec 19.
10
Infectious complications in the critically ill patient with cancer.患有癌症的重症患者的感染性并发症。
Semin Oncol. 2000 Jun;27(3):335-46.
引用本文的文献
1
Decrease in SinglePlex Viral PCRs Use and acyclovir utilization following implementation of The BioFire Meningitis/Encephalitis Panel at A Tertiary Care Cancer Center.在一家三级护理癌症中心实施BioFire脑膜炎/脑炎检测板后，单重病毒聚合酶链反应检测的使用及阿昔洛韦的使用量减少。
J Clin Virol Plus. 2025 Aug;5(3). doi: 10.1016/j.jcvp.2025.100221. Epub 2025 Jun 12.
2
Automated Radiosynthesis of [F]Fluoromannitol for Clinical Research on a Commercially Available Trasis AllinOne Radiosynthesizer.利用市售的Trasis AllinOne放射性合成仪自动合成用于临床研究的[F]氟甘露糖醇
Res Sq. 2025 Aug 1:rs.3.rs-7124066. doi: 10.21203/rs.3.rs-7124066/v1.
3
Phage Therapy in Managing Multidrug-Resistant (MDR) Infections in Cancer Therapy: Innovations, Complications, and Future Directions.噬菌体疗法在癌症治疗中应对多重耐药（MDR）感染的应用：创新、并发症及未来方向
Pharmaceutics. 2025 Jun 24;17(7):820. doi: 10.3390/pharmaceutics17070820.
4
The Invertebrate-Derived Antimicrobial Peptide Cm-p5 Induces Cell Death and ROS Production in Melanoma Cells.无脊椎动物源抗菌肽Cm-p5诱导黑色素瘤细胞死亡并产生活性氧。
Mar Drugs. 2025 Jun 29;23(7):273. doi: 10.3390/md23070273.
5
Analyzing potential of next-generation probiotics in cancer management.分析新一代益生菌在癌症管理中的潜力。
Mol Biol Rep. 2025 Jun 27;52(1):646. doi: 10.1007/s11033-025-10737-3.
6
Perspectives of healthcare professionals on the pharmacist's role in delivering vaccinations for patients with cancer: a qualitative study using role theory.医疗保健专业人员对药剂师在为癌症患者提供疫苗接种方面作用的看法：一项运用角色理论的定性研究
Int J Clin Pharm. 2025 Jun 16. doi: 10.1007/s11096-025-01945-9.
7
Association of time-to-treatment with prognosis in pneumocystis pneumonia among immunocompromised patients without HIV infection: a multi-center, retrospective observational cohort study.无HIV感染的免疫功能低下患者肺孢子菌肺炎治疗时间与预后的关联：一项多中心回顾性观察队列研究
BMC Infect Dis. 2025 Apr 15;25(1):531. doi: 10.1186/s12879-025-10933-3.
8
Clinical characteristics and prognostic factors of sepsis in patients with malignancy.恶性肿瘤患者脓毒症的临床特征及预后因素
Sci Rep. 2025 Feb 27;15(1):7078. doi: 10.1038/s41598-025-87457-y.
9
Unexpected Infective Endocarditis: Towards a New Alert for Clinicians.意外感染性心内膜炎：为临床医生敲响新警钟
J Clin Med. 2024 Aug 26;13(17):5058. doi: 10.3390/jcm13175058.
10
Infections in Humans-A Narrative Review.人类感染——一篇叙述性综述
Antibiotics (Basel). 2024 Jun 16;13(6):562. doi: 10.3390/antibiotics13060562.
本文引用的文献
1
Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China.新型冠状病毒肺炎（SARS-CoV-2）感染的癌症患者：一项中国全国性分析。
Lancet Oncol. 2020 Mar;21(3):335-337. doi: 10.1016/S1470-2045(20)30096-6. Epub 2020 Feb 14.
2
Impact of Catheter Management on Clinical Outcome in Adult Cancer Patients With Gram-Negative Bacteremia.导管管理对革兰氏阴性菌血症成年癌症患者临床结局的影响。
Open Forum Infect Dis. 2019 Sep 28;6(10):ofz357. doi: 10.1093/ofid/ofz357. eCollection 2019 Oct.
3
Shock and Early Death in Hematologic Patients with Febrile Neutropenia.发热性中性粒细胞减少症血液学患者的休克和早期死亡。
Antimicrob Agents Chemother. 2019 Oct 22;63(11). doi: 10.1128/AAC.01250-19. Print 2019 Nov.
4
Prevalence and Etiology of Community-acquired Pneumonia in Immunocompromised Patients.免疫功能低下患者社区获得性肺炎的患病率和病因。
Clin Infect Dis. 2019 Apr 24;68(9):1482-1493. doi: 10.1093/cid/ciy723.
5
Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European Conference on Infections in Leukaemia (ECIL 7).血液病患者和造血干细胞移植后巨细胞病毒感染管理指南，源自 2017 年白血病感染的欧洲会议（ECIL 7）。
Lancet Infect Dis. 2019 Aug;19(8):e260-e272. doi: 10.1016/S1473-3099(19)30107-0. Epub 2019 May 29.
6
Hepatosplenic candidiasis.肝脾念珠菌病
Clin Liver Dis (Hoboken). 2015 Aug 24;6(2):47-50. doi: 10.1002/cld.491. eCollection 2015 Aug.
7
Neutropenic Enterocolitis in Critically Ill Patients: Spectrum of the Disease and Risk of Invasive Fungal Disease.危重症患者中性粒细胞减少性肠炎：疾病谱和侵袭性真菌病的风险。
Crit Care Med. 2019 May;47(5):668-676. doi: 10.1097/CCM.0000000000003687.
8
Ureteral stent-associated infection and sepsis: pathogenesis and prevention: a review.输尿管支架相关感染与脓毒症：发病机制与预防：综述
Biofouling. 2019 Jan;35(1):117-127. doi: 10.1080/08927014.2018.1562549. Epub 2019 Feb 8.
9
Principles and Practice of Antibiotic Stewardship in the ICU.《重症加强治疗病房抗生素管理实践原则》。
Chest. 2019 Jul;156(1):163-171. doi: 10.1016/j.chest.2019.01.013. Epub 2019 Jan 25.
10
Respiratory Viral Infections in Patients With Cancer or Undergoing Hematopoietic Cell Transplant.癌症患者或接受造血细胞移植患者的呼吸道病毒感染
Front Microbiol. 2018 Dec 12;9:3097. doi: 10.3389/fmicb.2018.03097. eCollection 2018.
Zotero 插件