Bidzan Leszek, Bidzan Mariola
Department of Developmental Psychiatry, Psychotic and Geriatric Disorders, Medical University of Gdansk, Gdansk, Poland.
Institute of Psychology, University of Gdansk, Gdansk, Poland.
Neuropsychiatr Dis Treat. 2020 Nov 6;16:2677-2680. doi: 10.2147/NDT.S277740. eCollection 2020.
Sleep disorders, inversion of sleep rhythm, excessive daytime sleepiness, and sleeplessness at night are common in Alzheimer's disease (AD). Sleep disorders in AD have a diverse pathogenesis and their incidence increases as the disease progresses. Some publications indicate possible beneficial effects of methylphenidate on sleep. We presented two cases of patients with diagnosed AD accompanied by sleep disorders which had a significant impact on their functioning. The pathogenesis of sleep disorders was different in those two cases. In both case studies, the use of methylphenidate brought an immediate clinical effect, improving sleep at night and functioning during the day.
睡眠障碍、睡眠节律倒置、日间过度嗜睡和夜间失眠在阿尔茨海默病（AD）中很常见。AD中的睡眠障碍发病机制多样，且其发生率随疾病进展而增加。一些出版物表明哌醋甲酯对睡眠可能有有益作用。我们介绍了两例确诊为AD并伴有睡眠障碍的患者，这些睡眠障碍对他们的功能有重大影响。这两例患者睡眠障碍的发病机制不同。在这两个病例研究中，使用哌醋甲酯都带来了即时的临床效果，改善了夜间睡眠和日间功能。
