气相色谱-质谱碎片分析法对生物样品中阿密曲替林（S-1694）的定量分析。
Quantitative analysis of amineptine (S-1694) in biological samples by gas chromatography--mass fragmentography.
作者信息
Sbarra C, Negrini P, Fanelli R
出版信息
J Chromatogr. 1979 Jan 1;162(1):31-8. doi: 10.1016/s0378-4347(00)82060-5.
PMID:33193
Abstract
A sensitive, specific method for the quantitative analysis of amineptine in rat blood and brain is described. After extraction and purification amineptine is detected by mass fragmentography, monitoring the fragment ion at m/e 192. The method allows the quantitative analysis of as little as 50 ng of amineptine per ml blood and 200 ng per g for brain.
摘要
本文描述了一种灵敏、特异的大鼠血液和脑组织中阿密曲替林定量分析方法。阿密曲替林经提取和纯化后，通过质量碎片分析法进行检测，监测质荷比为192的碎片离子。该方法能够对每毫升血液中低至50纳克的阿密曲替林以及每克脑组织中低至200纳克的阿密曲替林进行定量分析。
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