Raguzzini Anna, Toti Elisabetta, Sciarra Tommaso, Fedullo Anna Lucia, Peluso Ilaria
Research Centre for Food and Nutrition, Council for Agricultural Research and Economics (CREA-AN), Rome, Italy.
Joint Veteran Center, Scientific Department, Army Medical Center, Rome, Italy.
Oxid Med Cell Longev. 2020 Oct 30;2020:9869851. doi: 10.1155/2020/9869851. eCollection 2020.
Urinary tract infection (UTI) is common in individuals with spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction (NLUTD) and in veterans with SCI who use antibiotics improperly for asymptomatic bacteriuria. Cranberry (CB) has been suggested for UTI prevention.
We performed a systematic search up to May 2020 in the following databases: AccessMedicine, BioMed Central, CINAHL, Cochrane Library, ProQuest, and PubMed. Quality assessment was performed using a specifically designed quality score. Risk ratio was calculated with both random effect model analysis (DerSimonian-Laird method) and quality effect model analysis (Doi Thalib method).
Six studies on bacteriuria and SCI were reviewed. From the four studies available for meta-analysis, two of which with individuals taking both CB and control, 477 data from 415 participants were analysed (241 CB and 236 control). No significant differences were detected with meta-analysis. However, bias, limitations, and incompleteness were observed in the reviewed studies.
Although further studies are needed, we suggest an accurate monitoring of diet and fluid intake, the evaluation of risk for potential food or nutraceutical interactions with drugs, and the inclusion of inflammatory markers among the outcomes in addition to UTI.
尿路感染（UTI）在脊髓损伤（SCI）和神经源性下尿路功能障碍（NLUTD）患者以及SCI退伍军人中很常见，这些退伍军人因无症状菌尿而不当使用抗生素。蔓越莓（CB）已被建议用于预防UTI。
我们在以下数据库中进行了截至2020年5月的系统检索：AccessMedicine、BioMed Central、CINAHL、Cochrane图书馆、ProQuest和PubMed。使用专门设计的质量评分进行质量评估。采用随机效应模型分析（DerSimonian-Laird方法）和质量效应模型分析（Doi Thalib方法）计算风险比。
对六项关于菌尿症和SCI的研究进行了综述。在可用于荟萃分析的四项研究中，其中两项研究的对象同时服用CB和对照药物，对来自415名参与者的477个数据进行了分析（241个CB组和236个对照组）。荟萃分析未发现显著差异。然而，在所审查的研究中观察到了偏差、局限性和不完整性。
尽管需要进一步研究，但我们建议准确监测饮食和液体摄入量，评估潜在食物或营养保健品与药物相互作用的风险，并在UTI之外将炎症标志物纳入研究结果中。
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