Wang Tian-Xing, Li Xiao-Xi, Chen Ling, Li Lin, Janaswamy Srinivas
Ministry of Education Engineering Research Center of Starch and Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Science and Engineering, South China University of Technology, Guangzhou, China.
Department of Dairy and Food Science, South Dakota State University, Brookings, SD, United States.
Front Chem. 2020 Sep 30;8:662. doi: 10.3389/fchem.2020.00662. eCollection 2020.
Herein, a self-assembly formulation of Zein and dextran sulfate sodium (DSS) binary complex has been developed for the quercetin (Que) delivery. The prepared particles display a smooth sphere in the range of 180 ~ 250 nm. The addition of DSS shields the Trp residues of Zein that were located on the hydrophilic exterior and in-turn reduces the surface hydrophobicity of the nanoparticles. The presence of DSS, indeed, increases the encapsulation efficiency of Que from the initial 45.9 in the Zein to 72.6% in the Zein/DSS binary complex. A significant reduction of Que diffusion in the simulated intestinal conditions has been observed with the addition of DSS on the nanoparticles, which also improves Que bioavailability. The release mechanism of Que-loaded Zein/DSS composites is in accordance with the Higuchi model (Q = 0.0913t+0.1652, = 0.953). Overall, nanoparticles based on Zein-DSS complexes stand out as an attractive carrier system of quercetin and the outcome could be extended to several bioactive compounds.
在此，已开发出一种玉米醇溶蛋白与硫酸葡聚糖钠（DSS）二元复合物的自组装制剂用于槲皮素（Que）递送。制备的颗粒呈现出180~250nm范围内的光滑球体。DSS的添加屏蔽了位于亲水性外部的玉米醇溶蛋白的色氨酸残基，进而降低了纳米颗粒的表面疏水性。实际上，DSS的存在使Que的包封效率从玉米醇溶蛋白中的初始45.9%提高到玉米醇溶蛋白/DSS二元复合物中的72.6%。在纳米颗粒上添加DSS后，在模拟肠道条件下观察到Que的扩散显著降低，这也提高了Que的生物利用度。载有Que的玉米醇溶蛋白/DSS复合材料的释放机制符合Higuchi模型（Q = 0.0913t + 0.1652， = 0.953）。总体而言，基于玉米醇溶蛋白-DSS复合物的纳米颗粒是一种有吸引力的槲皮素载体系统，其结果可扩展到几种生物活性化合物。
