Departments of Neurosurgery.
Radiology, Faculty of Medicine, Alanya Alaaddin Keykubat University, Alanya, Turkey.
Neuroreport. 2021 Jan 6;32(1):16-22. doi: 10.1097/WNR.0000000000001552.
This aim of this study was to assess the effect of idiopathic intracranial hypertension (IIH) in the development of intracranial hypertension by measuring patients' cerebrospinal fluid (CSF), brain, and segment volumes. IIH is a disease of unknown cause characterized by chronic CSF pressure elevation and papillary edema. Under the Monro-Kellie doctrine, efforts have been made to explain the disease through an increase in the volumes of one or two of brain, blood or CSF in the intracranial cavity, although these have not been completely successful.
Twelve IIH patients diagnosed based on the modified Dandy criteria and 15 age- and sex-compatible healthy controls were included in the study. Cases' 3D T1 sequence images were evaluated using the voxel-based volumetric analysis system (volBrain). Intracranial cavity extraction, macrostructures, and subcortical structure volumes were measured and compared.
No statistically significant differences were observed between control cases' and IIH patients' CSF, cerebrum, cerebellum, brainstem, and subcortical structure volumes.
IIH arises from a chronic cause that does not impair the volumetric balance between structures inside the intracerebral cavity.
本研究旨在通过测量患者的脑脊液（CSF）、脑和节段体积，评估特发性颅内高压（IIH）在颅内高压发展中的作用。IIH 是一种病因不明的疾病，其特征为慢性 CSF 压力升高和乳头水肿。根据 Monro-Kellie 学说，人们曾试图通过增加颅内腔中脑、血液或 CSF 的一个或两个体积来解释这种疾病，但并未完全成功。
本研究纳入了 12 名基于改良 Dandy 标准诊断的 IIH 患者和 15 名年龄和性别匹配的健康对照者。使用基于体素的容积分析系统（volBrain）对病例的 3D T1 序列图像进行评估。测量并比较了颅内腔提取、宏观结构和皮质下结构体积。
对照组和 IIH 患者的 CSF、大脑、小脑、脑干和皮质下结构体积之间无统计学显著差异。
IIH 是由慢性原因引起的，不会损害颅内腔内部结构之间的容积平衡。
