School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, 3010, Victoria, Australia.
Chem Commun (Camb). 2020 Dec 7;56(95):15060-15063. doi: 10.1039/d0cc06263d.
The C-type lectin receptor Mincle binds Candida albicans and has been implicated in its pathobiology, but the molecular effectors responsible have not been identified. We report the synthesis of cholesteryl and ergosteryl 6-O-acyl-α-d-mannosides, produced by C. albicans mycelium, and demonstrate their ability to signal through human and mouse Mincle.
C 型凝集素受体 Mincle 与白色念珠菌结合，并与其发病机制有关，但尚未确定其负责的分子效应物。我们报告了白念珠菌菌丝体产生的胆甾醇和麦角甾醇 6-O-酰基-α-d-甘露糖苷的合成，并证明它们能够通过人和小鼠 Mincle 发出信号。
