J Drugs Dermatol. 2020 Nov 1;19(11):1065-1068. doi: 10.36849/JDD.2020.2229.
Actinic keratosis (AK) is a common intraepithelial atypical proliferation of keratinocytes that might progress into invasive squamous cell carcinoma.
We have tested the treatment using sequential sessions of photodynamic therapy in daylight and injectable non-animal hyaluronic acid gel skin boosters (NSBs) on 4 patients with AK on head and neck. Two further sessions of NSBs were scheduled, 30 and 60 days after the first injection, to improve the overall skin quality.
All patients showed a clinically significant improvement of the overall face skin quality, photoaging signs, and fine wrinkles; all patients were satisfied of the treatment outcome. None of the patients reported any side effect related to the treatment.
The combination of two minimally invasive treatments showed to be effective giving the almost complete resolution of AK and a clear improvement of skin texture, with noticeable reduction of the clinical signs of skin photoaging, meeting patient’s expectations. J Drugs Dermatol. 2020;19(11): doi:10.36849/JDD.2020.2229.
光化性角化病（AK）是一种常见的角质形成细胞上皮内非典型增生，可能进展为侵袭性鳞状细胞癌。
我们已经测试了使用光动力疗法在日光下进行序贯治疗和注射用非动物透明质酸凝胶皮肤增强剂（NSB）治疗 4 例头颈部 AK 的效果。在第一次注射后 30 天和 60 天，安排了另外两次 NSB 治疗，以改善整体皮肤质量。
所有患者的面部皮肤整体质量、光老化迹象和细小皱纹均有明显改善，所有患者均对治疗效果满意。患者均未报告与治疗相关的任何不良反应。
两种微创治疗方法的联合应用显示出有效性，AK 几乎完全消退，皮肤质地明显改善，皮肤光老化的临床征象明显减轻，满足了患者的期望。J 皮肤病药物杂志。2020;19(11):doi:10.36849/JDD.2020.2229.
