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[术中血管空气栓塞:风险、诊断及治疗的证据]

[Intraoperative vascular air embolism : Evidence for risks, diagnostics and treatment].

作者信息

Michels P, Meyer E C, Brandes I F, Bräuer A

机构信息

Klinik für Anästhesiologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37099, Göttingen, Deutschland.

出版信息

Anaesthesist. 2021 May;70(5):361-375. doi: 10.1007/s00101-020-00894-4.

Abstract

The entry of gases into the vascular system is called vascular air embolism (VAE). The blocking of the pulmonary circulation by VAE can lead to fulminant right-sided heart failure and cardiocirculatory arrest. A VAE can occur at any time if there is an open connection between the environment and a venous vessel with subatmospheric pressure. This situation occurs during ear nose throat surgery, hip surgery, surgery of the lesser pelvis or breast surgery, if the surgical field is above the level of the heart; however, a VAE can also occur during routine tasks, such as insertion or removal of a central venous catheter or during endoscopic procedures with the insufflation of gas.Because during these procedures VAE is not the main focus of the anesthesia or surgery personnel, in such situations its sudden unexpected occurrence can have severe consequences. In contrast, in cardiac surgery or neurosurgery the risk of intraoperative VAE is much better known. In procedures with a higher risk of a clinically relevant VAE, a patent foramen ovale should be ruled out by preoperative transesophageal echocardiography (TEE). Intraoperatively TEE is the most sensitive procedure not only to detect a VAE but also to visualize the clinical expression, e.g. acute right heart overload.The avoidance of an initial and repeated air embolism is the primary measure to minimize the incidence and severity of VAE.Intraoperatively the following measures should be undertaken: excellent communication between anesthesia and surgery personnel with predetermined actions, maintenance of normal volume, patient positioning with minimal difference in height between heart and head, state of the art surgical technique with closure of potential air entry sites, sufficient detection of air by TEE, repeated jugular vein compression during neurosurgery, intraoperative Trendelenburg positioning of the patient during persisting or clinically evident VAE, differentiated adjustment of ventilatory settings and catecholamine treatment, aspiration of the blood-air mixture (air lock) at the junction of the superior vena cava and right atrium through a large bore central venous line and keeping check of the coagulation status.

摘要

气体进入血管系统被称为血管空气栓塞(VAE)。VAE阻塞肺循环可导致暴发性右侧心力衰竭和心循环骤停。如果环境与处于低于大气压的静脉血管之间存在开放连接,VAE可在任何时候发生。这种情况发生在耳鼻喉手术、髋关节手术、小骨盆手术或乳房手术中,如果手术区域高于心脏水平;然而,VAE也可发生在常规操作过程中,如插入或拔除中心静脉导管或在内镜检查时注入气体。因为在这些操作过程中,VAE不是麻醉或手术人员的主要关注点,在这种情况下其突然意外发生可能会产生严重后果。相比之下,在心脏手术或神经外科手术中,术中VAE的风险更为人所知。在具有较高临床相关VAE风险的手术中,应通过术前经食管超声心动图(TEE)排除卵圆孔未闭。术中TEE是最敏感的检查方法,不仅能检测到VAE,还能观察到临床表现,如急性右心负荷过重。避免初始和反复的空气栓塞是将VAE的发生率和严重程度降至最低的主要措施。术中应采取以下措施:麻醉和手术人员之间进行良好沟通并采取预定行动,维持正常血容量,患者体位保持心脏和头部高度差最小,采用先进的手术技术封闭潜在的空气进入部位,通过TEE充分检测空气,神经外科手术中反复压迫颈静脉,在持续或临床明显的VAE期间将患者术中置于头低脚高位,区别调整通气设置和进行儿茶酚胺治疗,通过大口径中心静脉导管在上腔静脉与右心房交界处抽吸血液-空气混合物(气栓)并检查凝血状态。

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