Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Member of Interactive Dermatology Research Foundation, Egypt.
J Dtsch Dermatol Ges. 2021 Feb;19(2):241-246. doi: 10.1111/ddg.14316. Epub 2020 Nov 16.
Several modalities have been used to clear residual facial pigmentation in patients with extensive vitiligo; however, the ideal depigmenting agent does not yet exist. The use of trichloroacetic acid (TCA) for depigmentation in universal vitiligo has been recently reported. We aim to evaluate the efficacy and safety of TCA 100 % as a depigmenting therapy for recalcitrant facial pigmentation in Egyptian patients with universal vitiligo.
The study included 50 patients with universal vitiligo who had residual spotted pigmentation on the face causing psychological distress. TCA was focally applied to cover the pigmented patches at 100 % concentration. The treatment was repeated every two weeks until complete depigmentation or for a maximum of five treatment sessions.
Excellent response to TCA treatment (> 90 % depigmentation) was reported in 80 % of the studied cases, partial response (50-90 % depigmentation) in 12 % and poor response (< 50 % depigmentation) in 8 % of the cases. Minor adverse effects were reported e.g. burning sensation, erosions and local infection.
TCA seems to be a cost-effective and well tolerated therapeutic option for the treatment of recalcitrant residual pigmentation in patients with extensive vitiligo. This modality is associated with reduced downtime and minimal adverse effects.
为清除广泛型白癜风患者的残余面部色素沉着，已经采用了多种方法；然而，目前还没有理想的脱色剂。最近有报道称，100%三氯乙酸（TCA）可用于泛发性白癜风的脱色。我们旨在评估 TCA 100%作为一种脱色疗法，用于治疗埃及泛发性白癜风患者难治性面部色素沉着的疗效和安全性。
该研究纳入了 50 名广泛型白癜风患者，他们的面部有残留的斑点色素沉着，导致心理困扰。TCA 以 100%浓度局部应用于覆盖色素沉着斑块。治疗每两周重复一次，直至完全脱色或最多进行五次治疗。
80%的研究病例报告 TCA 治疗有极好的反应（>90%的脱色），12%有部分反应（50-90%的脱色），8%有较差的反应（<50%的脱色）。报告了轻微的不良反应，如烧灼感、糜烂和局部感染。
TCA 似乎是治疗广泛型白癜风患者难治性残余色素沉着的一种经济有效且耐受性良好的治疗选择。这种方法与减少停机时间和最小化不良反应有关。
