Loewit K, Huber J, Ortlieb A, Kraft H G, Widhalm R, Wolfram G
Institut für Medizinische Biologie und Genetik der Universität Innsbruck.
Geburtshilfe Frauenheilkd. 1987 Nov;47(11):800-2. doi: 10.1055/s-2008-1036050.
A radioimmunological method of salivary LH determination has been developed as a new non invasive approach to hormonal ovulation detection. In this study salivary LH patterns have been compared to serum LH peak and daily sonographic assessment of follicle maturation in 15 spontaneous cycles of 9 women experienced in self-observation of their cycles (NFP). The day where the mature follicle was no longer visible sonographically was labelled day 0. Serum LH peaks occurred in 11 out of 15 cycles on day -1, two times on days -2 and 0 and preceded salivary LH peaks in 8 out of 15 cycles. The latter coincided in 7 cycles with day 0 in two cycles each with days -1 and +1 and in 4 cycles with day -2. Thus 13/15 serum- and 11/15 salivary-LH peaks occurred within +/- one day of the disappearance of the mature follicle. A time lag of up to six hours between the sampling of saliva and serum might explain the difference in the respective peak days, however, more studies into the kinetics of LH transport and its circadian rhythmicity seem necessary. Nevertheless, in principle also the salivary LH peak is considered a suitable indicator of ovulation.
一种唾液促黄体生成素（LH）测定的放射免疫方法已被开发出来，作为一种检测激素性排卵的新型非侵入性方法。在本研究中，对9名有月经周期自我观察经验（自然计划生育法）的女性的15个自然周期中的唾液LH模式与血清LH峰值以及卵泡成熟度的每日超声评估进行了比较。超声检查中成熟卵泡不再可见的那天被标记为第0天。15个周期中有11个周期的血清LH峰值出现在第-1天，有2个周期出现在第-2天和第0天，并且在15个周期中有8个周期血清LH峰值先于唾液LH峰值出现。后者在7个周期中与第0天一致，在2个周期中与第-1天和第+1天一致，在4个周期中与第-2天一致。因此，15个周期中有13个周期的血清LH峰值和15个周期中有11个周期的唾液LH峰值出现在成熟卵泡消失的±1天内。唾液和血清采样之间长达6小时的时间间隔可能解释了各自峰值日期的差异，然而，似乎有必要对LH转运动力学及其昼夜节律进行更多研究。尽管如此，原则上唾液LH峰值也被认为是排卵的合适指标。
