Integrated Brain Health Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, USA; Harvard Medical School, USA.
Division of Neuropsychiatry, Department of Psychiatry & Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, USA.
Complement Ther Med. 2021 Jan;56:102581. doi: 10.1016/j.ctim.2020.102581. Epub 2020 Oct 20.
Neurofibromatosis type 2 (NF2) is a rare, progressive and incurable genetic disorder associated with progressive hearing loss and eventual deafness. As a group, patients with NF report high levels of stress and depressive symptoms. However, no studies have explored improvement in these symptoms after psychosocial interventions. We have previously shown that a mind-body program tailored to adults with NF2 who are deaf (the Relaxation Response and Resiliency Program for Deaf NF2, d3RP-NF2) improves quality of life and resiliency over and above a Health Enhancement program when both are delivered via live-video and assisted by Communication Access Realtime Translation (CART). Here we tested the effects of the programs on depression and perceived stress.
Forty-five patients with NF2 and significant hearing loss were randomized to the d3RP-NF2 or Health-Enhancement program and completed measures of depression (PHQ-9) and perceived stress (PSS-10) at baseline, post-intervention, and six-month follow-up.
Patients randomized to the d3RP-NF2 program, but not to the control condition, experienced significant decreases on both measures from baseline to post-test, which were maintained at follow-up (within group tests). However, improvements following the d3RP-NF2 program was not significantly higher than those observed in the control group (between group tests).
Results provide the first evidence of improvement in symptoms of depression and perceived stress among deaf patients living with NF2 who participate in a virtual mind-body program.
神经纤维瘤病 2 型（NF2）是一种罕见的、进行性的、无法治愈的遗传性疾病，与进行性听力损失和最终失聪有关。作为一个群体，NF 患者报告有高水平的压力和抑郁症状。然而，目前还没有研究探讨心理社会干预后这些症状的改善情况。我们之前已经表明，针对 NF2 耳聋患者（聋人 NF2 的放松反应和适应力计划，d3RP-NF2）量身定制的身心计划，在通过实时视频提供并由实时翻译（CART）辅助的情况下，在健康增强计划的基础上，改善生活质量和适应力。在这里，我们测试了这些计划对抑郁和感知压力的影响。
45 名 NF2 伴显著听力损失的患者被随机分配到 d3RP-NF2 或健康增强计划组，并在基线、干预后和 6 个月随访时完成抑郁（PHQ-9）和感知压力（PSS-10）的测量。
随机分配到 d3RP-NF2 计划组的患者，而不是对照组，在基线到后测期间，在两个测量指标上都显著下降，并且在随访时保持不变（组内测试）。然而，d3RP-NF2 计划组的改善并不显著高于对照组（组间测试）。
结果提供了第一个证据，表明参与虚拟身心计划的 NF2 耳聋患者的抑郁和感知压力症状有所改善。
