Spence Michael W, Fox William A, Gardner Janet, Beauchesne Patrick
Department of Anthropology, University of Western Ontario, London, Ontario N6A 5C2, Canada.
Department of Anthropology, Trent University, Peterborough, Ontario K9L 0G2, Canada.
Int J Paleopathol. 2021 Mar;32:9-16. doi: 10.1016/j.ijpp.2020.10.007. Epub 2020 Nov 13.
To examine a possible case of Paget's disease of bone (PDB) in an Indigenous pre-contact male from Canada, individual D of the Skinner site in Ontario.
Radiographs, CT scan and histological analysis.
The histological analysis revealed the mosaic pattern that characterizes PDB. CT scans show advanced sclerosis of the cranium and a diminished diplӧe with osteolytic lesions.
The pathological features that have been identified are collectively characteristic of PDB.
The Skinner case advances our understanding of the global history and distribution of PDB.
Only two New World cases have been identified and neither has been studied in sufficient detail.
The older individuals in precolonial New World skeletal series should be given CT scans, which are non-intrusive, to be followed by histological and genetic analyses when indicated.
研究加拿大安大略省斯金纳遗址中一位接触前的原住民男性个体D可能患有的骨佩吉特病（PDB）病例。
X线摄影、CT扫描和组织学分析。
组织学分析显示出PDB特有的镶嵌模式。CT扫描显示颅骨严重硬化，板障减少并伴有溶骨性病变。
已确定的病理特征共同构成了PDB的特征。
斯金纳病例增进了我们对PDB全球历史和分布的理解。
仅鉴定出两例新世界病例，且均未进行充分详细的研究。
对前殖民时期新世界骨骼系列中的年长者进行非侵入性的CT扫描，必要时随后进行组织学和基因分析。
