Institut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France.
Institut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France.
Curr Opin Neurobiol. 2021 Feb;66:135-143. doi: 10.1016/j.conb.2020.10.009. Epub 2020 Nov 13.
Reelin, a glycoprotein of the extracellular matrix, has been the focus of several studies over the years, mostly for its role in cell migration. Here we report the role of this molecule and of its downstream pathways in post-mitotic neurons and how they contribute to neural circuit assembly, refinement and function. Accumulating evidence has pointed at a major role for Reelin in axonal guidance, synaptogenesis and dendritic spine formation. In particular, new evidence points at a direct role in axonal targeting and refinement at the target site. In addition, recent advances highlight new functions of Reelin in the modulation of synaptic activity, plasticity and behavior and in the direct regulation of GABA receptors expression and stability. We discuss these findings in the context of neurodevelopmental disorders.
瑞林蛋白(reelin)是细胞外基质中的一种糖蛋白，多年来一直是多项研究的重点，主要是因为它在细胞迁移中的作用。在这里，我们报告了这种分子及其下游途径在有丝分裂后神经元中的作用，以及它们如何有助于神经回路的组装、细化和功能。越来越多的证据表明 Reelin 在轴突导向、突触形成和树突棘形成中起着重要作用。特别是，新的证据表明它在轴突靶向和在靶部位的细化中起着直接作用。此外，最近的进展强调了 Reelin 在调节突触活动、可塑性和行为以及直接调节 GABA 受体表达和稳定性方面的新功能。我们将这些发现置于神经发育障碍的背景下进行讨论。
