Domșa Ana-Maria Teodora, Gheban Dan, Lazăr Camelia, Pop Bogdan, Borzan Cristina Maria
Department of Pathology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania.
J Clin Med. 2020 Nov 12;9(11):3639. doi: 10.3390/jcm9113639.
Current pediatric guidelines recommend the use of the Updated Sydney Classification for gastritis to assess histological changes caused by () infection. The purpose of this study was to investigate the morphometric alterations of the antral mucosa in relation to pediatric infection.
A total of 65 cases were considered eligible. Apart from scoring the biopsies according to the recommendations, foveolar hyperplasia (FH) was assessed. The following measurements were performed on digital slides: total mucosal thickness, foveolar and glandular length, number of glandular cross sections per 40X field, glandular diameter, and distance between glands.
The thickness of the antral mucosa increased along with the bacterial density and the intensity of inflammation in -infected children ( < 0.05). FH was significantly associated with the presence of ( < 0.001) and also exhibited a greater length of the foveolar and glandular structures and an increased glandular diameter ( < 0.05), but without influencing the thickness of the mucosa.
Our results reinforce the fact that FH is not only an important histologic characteristic of gastropathy, but is also a significant change observed in infection in children and may be considered for reporting when evaluating pediatric gastric biopsies.
当前儿科指南推荐使用更新后的悉尼胃炎分类法来评估由（）感染引起的组织学变化。本研究的目的是调查与儿科（）感染相关的胃窦黏膜形态计量学改变。
共65例被认为符合条件。除了根据建议对活检进行评分外，还评估了小凹增生（FH）。在数字载玻片上进行了以下测量：黏膜总厚度、小凹和腺体长度、每40倍视野下腺体横截面积、腺体直径以及腺体之间的距离。
在（）感染儿童中，胃窦黏膜厚度随细菌密度和炎症强度增加而增加（<0.05）。FH与（）的存在显著相关（<0.001），并且还表现出小凹和腺体结构长度更长以及腺体直径增加（<0.05），但不影响黏膜厚度。
我们的结果强化了这样一个事实，即FH不仅是胃病的重要组织学特征，也是在儿童（）感染中观察到的显著变化，并且在评估儿科胃活检时可考虑报告。
