Charloux A, Enache I, Pistea C, Olland A
Pôle de pathologie thoracique, service de physiologie et d'explorations fonctionnelles, hôpitaux universitaires de Strasbourg, Strasbourg, France.
Pôle de pathologie thoracique, service de physiologie et d'explorations fonctionnelles, hôpitaux universitaires de Strasbourg, Strasbourg, France.
Rev Mal Respir. 2020 Dec;37(10):800-810. doi: 10.1016/j.rmr.2020.07.007. Epub 2020 Nov 13.
Surgery is the best treatment for early lung cancer but requires a preoperative functional evaluation to identify patients who may be at a high risk of complications or death. Guideline algorithms include a cardiological evaluation, a cardiopulmonary assessment to calculate the predicted residual lung function, and identify patients needing exercise testing to complete the evaluation. According to most expert opinion, exercise tests have a very high predictive value of complications. However, since the publication of these guidelines, minimally-invasive surgery, sublobar resections, prehabilitation and enhanced recovery after surgery (ERAS) programmes have been developed. Implementation of these techniques and programs is associated with a decrease in postoperative mortality and complications. In addition, the current guidelines and the cut-off values they identified are based on early series of patients, and are designed to select patients before major lung resection (lobectomy-pneumonectomy) performed by thoracotomy. Therefore, after a review of the current guidelines and a brief update on prehabilitation (smoking cessation, exercise training and nutritional aspects), we will discuss the need to redefine functional criteria to select patients who will benefit from lung surgery.
手术是早期肺癌的最佳治疗方法,但术前需要进行功能评估,以识别可能出现高并发症风险或死亡风险的患者。指南算法包括心脏评估、心肺评估以计算预计的残余肺功能,以及识别需要进行运动测试以完成评估的患者。根据大多数专家意见,运动测试对并发症具有很高的预测价值。然而,自这些指南发布以来,已经开发了微创手术、肺叶下切除术、术前康复和术后加速康复(ERAS)计划。这些技术和计划的实施与术后死亡率和并发症的降低相关。此外,当前的指南及其确定的临界值是基于早期的患者系列,旨在选择在通过开胸进行的主要肺切除术(肺叶切除术-全肺切除术)之前的患者。因此,在回顾当前指南并简要更新术前康复(戒烟、运动训练和营养方面)之后,我们将讨论重新定义功能标准以选择将从肺部手术中受益的患者的必要性。