从 中分离得到的两种新的氮杂菲酮类色素及其抗炎活性。
Two new azaphilone pigments from and their anti-inflammatory activity.
机构信息
State Key Laboratory Cultivation Base for Traditional Chinese Medicine Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China.
出版信息
J Asian Nat Prod Res. 2021 Apr;23(4):325-332. doi: 10.1080/10286020.2020.1847093. Epub 2020 Nov 17.
Two new azaphilone pigments, talaralbols A and B ( and ), along with five known azaphilone metabolites (, , and -), were isolated from the culture of associated with the isopod . Their structures were elucidated by a combination of 1 D and 2 D NMR data, ECD calculations, chemical transformations, and NMR data analogy with model compounds. Talaralbol A () showed a moderate inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells with the inhibitory rate being 31.0% at the concentration of 10 M.[Formula: see text].
两种新的氮杂菲酮类色素，talaralbols A 和 B（和），以及五种已知的氮杂菲酮代谢物（，，和-），从与等足类相关的培养物中分离出来。通过 1D 和 2D NMR 数据、ECD 计算、化学转化以及与模型化合物的 NMR 数据类比，确定了它们的结构。talaralbol A（）在 LPS 诱导的 RAW264.7 细胞中对一氧化氮（NO）的产生显示出中等抑制作用，在 10 μM 浓度下抑制率为 31.0%。[公式：见正文]。
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