特发性颅内高压的新视野：进展与挑战。
New horizons for idiopathic intracranial hypertension: advances and challenges.
机构信息
Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, Birmingham, UK.
Metabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
出版信息
Br Med Bull. 2020 Dec 15;136(1):118-126. doi: 10.1093/bmb/ldaa034.
INTRODUCTION
Idiopathic intracranial hypertension (IIH) is becoming a recognized condition due to the increasing incidence linked to a global obesity epidemic.
SOURCES OF DATA
All English papers on PubMed, Cochrane and Scholar between inception until 1 March 2020 were considered.
AREAS OF AGREEMENT
Studies suggest central adiposity has a pathogenic role. Recent weight gain is a risk factor and weight loss has a key role in management.
AREAS OF CONTROVERSY
Interpretation of abnormal lumbar puncture opening pressure is debated. There is an increasing recognition of obesity stigma and how this should be approached.
GROWING POINTS
Further evidence is required for the choice of surgical intervention for fulminant IIH. Education regarding IIH should be evidence based.
AREAS TIMELY FOR DEVELOPING RESEARCH
Novel research of the pathology of IIH is influencing development of therapies such as glucagon-like peptide-1 receptor agonists and targeting unique androgen signatures. The newly discovered cardiovascular risk requires further attention.
简介
特发性颅内高压（IIH）的发病率因全球肥胖症的流行而不断上升，因此这种疾病逐渐受到人们的关注。
资料来源
在 2020 年 3 月 1 日之前，我们在 PubMed、Cochrane 和 Scholar 数据库中检索了所有关于 IIH 的英文文献。
意见一致之处
研究表明中心性肥胖与 IIH 的发病机制有关。近期体重增加是 IIH 的一个危险因素，而减轻体重在 IIH 的治疗中起着关键作用。
争议之处
对异常腰椎穿刺压力的解读存在争议。人们越来越认识到肥胖带来的耻辱感，以及应该如何应对这种耻辱感。
发展点
需要更多的证据来选择治疗暴发性 IIH 的手术干预措施。有关 IIH 的教育应基于证据。
需要及时研究的领域
对 IIH 病理的新研究正在推动胰高血糖素样肽-1 受体激动剂等疗法的发展，并针对独特的雄激素特征进行靶向治疗。新发现的心血管风险需要进一步关注。
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