miRNAs 作为创伤性脑损伤的潜在生物标志物：从诊断到神经康复的途径。
miRNAs as Potential Biomarkers for Traumatic Brain Injury: Pathway From Diagnosis to Neurorehabilitation.
机构信息
Research Service and the Center for Innovation in Complex Chronic Healthcare, Edward Hines Jr, VA Hospital, Hines, Illinois (Drs Herrold, Kletzel, Saban, Bhaumik, Radke, and Bender Pape); Departments of Psychiatry and Behavioral Sciences (Dr Herrold) and Physical Medicine and Rehabilitation (Dr Bender Pape), Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Otolaryngology-Head and Neck Surgery, Loyola University Chicago, Maywood, Illinois (Dr Foecking); Research Service, Edward Hines Jr, VA Hospital, Hines, Illinois (Dr Foecking); Chicago Association for Research and Education in Science (CARES), Hines, Illinois (Dr Foecking and Ms Salinas); Marcella Niehoff School of Nursing, Loyola University Chicago, Maywood, Illinois (Dr Saban), Department of Neurological Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois (Dr Przybycien-Szymanska); Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois (Dr Zilliox); Cooperative Studies Program, Coordinating Center, Edward Hines Jr, VA Hospital, Hines, Illinois (Dr Bhaumik); Department of Psychiatry, University of Illinois at Chicago (UIC) (Dr Bhaumik); Chez Veterans Center at the University of Illinois, Urbana-Champaign (Dr Lange); and Infectious Diseases and Immunology Research Institute (Dr Radke) and Division of Infectious Diseases (Dr Radke), Loyola University Chicago-Stritch School of Medicine, Maywood, Illinois.
出版信息
J Head Trauma Rehabil. 2021;36(3):E155-E169. doi: 10.1097/HTR.0000000000000632.
BACKGROUND
Biomarkers that can advance precision neurorehabilitation of the traumatic brain injury (TBI) are needed. MicroRNAs (miRNAs) have biological properties that could make them well suited for playing key roles in differential diagnoses and prognoses and informing likelihood of responsiveness to specific treatments.
OBJECTIVE
To review the evidence of miRNA alterations after TBI and evaluate the state of science relative to potential neurorehabilitation applications of TBI-specific miRNAs.
METHODS
This scoping review includes 57 animal and human studies evaluating miRNAs after TBI. PubMed, Scopus, and Google Scholar search engines were used.
RESULTS
Gold standard analytic steps for miRNA biomarker assessment are presented. Published studies evaluating the evidence for miRNAs as potential biomarkers for TBI diagnosis, severity, natural recovery, and treatment-induced outcomes were reviewed including statistical evaluation. Growing evidence for specific miRNAs, including miR21, as TBI biomarkers is presented.
CONCLUSIONS
There is evidence of differential miRNA expression in TBI in both human and animal models; however, gaps need to be filled in terms of replication using rigorous, standardized methods to isolate a consistent set of miRNA changes. Longitudinal studies in TBI are needed to understand how miRNAs could be implemented as biomarkers in clinical practice.
背景
需要能够推进创伤性脑损伤 (TBI) 精准神经康复的生物标志物。microRNAs (miRNAs) 具有生物学特性，使其非常适合在鉴别诊断和预后中发挥关键作用，并为特定治疗的反应可能性提供信息。
目的
综述 TBI 后 miRNA 变化的证据，并评估 TBI 特异性 miRNAs 用于神经康复应用的科学现状。
方法
本范围综述包括 57 项评估 TBI 后 miRNA 的动物和人类研究。使用了 PubMed、Scopus 和 Google Scholar 搜索引擎。
结果
提出了 miRNA 生物标志物评估的金标准分析步骤。综述了评估 miRNA 作为 TBI 诊断、严重程度、自然恢复和治疗诱导结果潜在生物标志物的研究，包括统计评估。提出了 miR21 等特定 miRNA 作为 TBI 生物标志物的证据越来越多。
结论
在人类和动物模型中均有 TBI 中 miRNA 表达差异的证据；然而，需要使用严格、标准化的方法来复制，以确定一组一致的 miRNA 变化，从而填补这方面的空白。需要对 TBI 进行纵向研究，以了解如何将 miRNAs 作为生物标志物应用于临床实践。
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