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[晚期前列腺癌的全身治疗]

[Systemic treatment of advanced prostate cancer].

作者信息

Kretschmer Alexander, Todenhöfer Tilman

机构信息

Urologische Klinik und Poliklinik, Klinikum der Universität München, Ludwig-Maximilians-Universität, Marchioninistr. 15, 81377, München, Deutschland.

Studienpraxis Nürtingen, Steinengrabenstraße 17, 72622, Nürtingen, Deutschland.

出版信息

Urologe A. 2020 Dec;59(12):1565-1576. doi: 10.1007/s00120-020-01381-9.

DOI:10.1007/s00120-020-01381-9
PMID:33201295
Abstract

In recent years there have been substantial changes in the therapeutic landscape for systemic treatment of advanced prostate cancer (PCa), which resulted in a multitude of novel treatment options for different stages of the disease. In the current narrative review currently available treatment options for metastatic hormone-sensitive PCa as well as nonmetastatic castration-resistant PCa are presented. In addition, current treatment sequence options and targeted treatment in the stage of metastatic castration-resistant PCa are highlighted.

摘要

近年来,晚期前列腺癌(PCa)全身治疗的治疗格局发生了重大变化,这为该疾病的不同阶段带来了众多新的治疗选择。在本叙述性综述中,介绍了目前转移性激素敏感性PCa以及非转移性去势抵抗性PCa的可用治疗选择。此外,还重点介绍了转移性去势抵抗性PCa阶段目前的治疗顺序选择和靶向治疗。

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本文引用的文献

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Initial Experience with Radical Prostatectomy Following Holmium Laser Enucleation of the Prostate.钬激光前列腺剜除术后行根治性前列腺切除术的初步经验。
Eur Urol Focus. 2021 Nov;7(6):1247-1253. doi: 10.1016/j.euf.2020.09.003. Epub 2020 Sep 19.
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PARP inhibitors in castration-resistant prostate cancer.聚腺苷二磷酸核糖聚合酶抑制剂在去势抵抗性前列腺癌中的应用。
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Comparative efficacy of apalutamide darolutamide and enzalutamide for treatment of non-metastatic castrate-resistant prostate cancer: A systematic review and network meta-analysis.
阿帕鲁胺、达罗他胺和恩扎卢胺治疗去势抵抗性前列腺癌非转移性前列腺癌的疗效比较:系统评价和网络荟萃分析。
Urol Oncol. 2020 Nov;38(11):826-834. doi: 10.1016/j.urolonc.2020.03.022. Epub 2020 Jun 28.
4
Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer.恩扎卢胺与非转移性去势抵抗性前列腺癌的生存。
N Engl J Med. 2020 Jun 4;382(23):2197-2206. doi: 10.1056/NEJMoa2003892. Epub 2020 May 29.
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Olaparib for Metastatic Castration-Resistant Prostate Cancer.奥拉帕利治疗转移性去势抵抗性前列腺癌。
N Engl J Med. 2020 May 28;382(22):2091-2102. doi: 10.1056/NEJMoa1911440. Epub 2020 Apr 28.
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Effect of Enzalutamide plus Androgen Deprivation Therapy on Health-related Quality of Life in Patients with Metastatic Hormone-sensitive Prostate Cancer: An Analysis of the ARCHES Randomised, Placebo-controlled, Phase 3 Study.恩扎卢胺联合雄激素剥夺治疗对转移性激素敏感前列腺癌患者健康相关生活质量的影响:ARCHES 随机、安慰剂对照、III 期研究分析。
Eur Urol. 2020 Oct;78(4):603-614. doi: 10.1016/j.eururo.2020.03.019. Epub 2020 Apr 23.
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A Systematic Review and Network Meta-analysis of Novel Androgen Receptor Inhibitors in Non-metastatic Castration-resistant Prostate Cancer.新型雄激素受体抑制剂在非转移性去势抵抗性前列腺癌中的系统评价和网络荟萃分析。
Clin Genitourin Cancer. 2020 Oct;18(5):343-350. doi: 10.1016/j.clgc.2020.02.005. Epub 2020 Mar 6.
8
[Combination therapy for metastatic hormone-sensitive prostate cancer: What? When? For whom?].[转移性激素敏感性前列腺癌的联合治疗:是什么?何时进行?适用于谁?]
Urologe A. 2020 Jun;59(6):665-672. doi: 10.1007/s00120-020-01189-7.
9
Optimal sequencing of enzalutamide and abiraterone acetate plus prednisone in metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase 2, crossover trial.转移性去势抵抗性前列腺癌中恩扎卢胺和醋酸阿比特龙联合泼尼松序贯治疗的最佳顺序:一项多中心、随机、开放标签、2 期、交叉试验。
Lancet Oncol. 2019 Dec;20(12):1730-1739. doi: 10.1016/S1470-2045(19)30688-6. Epub 2019 Nov 11.
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Health-related quality of life after apalutamide treatment in patients with metastatic castration-sensitive prostate cancer (TITAN): a randomised, placebo-controlled, phase 3 study.阿帕他胺治疗转移性去势敏感性前列腺癌(TITAN)患者的健康相关生活质量:一项随机、安慰剂对照、III 期研究。
Lancet Oncol. 2019 Nov;20(11):1518-1530. doi: 10.1016/S1470-2045(19)30620-5. Epub 2019 Sep 29.