Department of Immunoendocrinology, Medical University of Lodz, Poland.
Department of Neuroendocrinology, Medical University of Lodz, Poland.
Neuro Endocrinol Lett. 2020 Sep;41(3):118-122.
The paper presents the evaluation of a hypothesis assuming that the elevated levels of gonadotropins which occur physiologically in older persons are involved by their direct extra-gonadal action in the pathogenesis of age-related disorders. The data on the possibilities of the direct action of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and their possible deleterious effects in the brain, bone, cardiovascular system and cancer in older persons are reviewed. A proposal of a new approach to the hormonal prevention treatment of age-related disorders (suppression of gonadotropins by means of gonadotropin releasing hormone analogs) is discussed.
本文评价了一个假说，即老年人中生理上升高的促性腺激素水平通过其在与年龄相关的疾病发病机制中的直接性腺外作用而涉及其中。本文回顾了关于卵泡刺激素（FSH）和黄体生成素（LH）直接作用的可能性及其在老年人的大脑、骨骼、心血管系统和癌症中的可能有害影响的资料。本文还讨论了一种新的针对与年龄相关的疾病的激素预防治疗方法（通过使用促性腺激素释放激素类似物抑制促性腺激素）的建议。
